From: 
Linda Iroff 
Date: 2001-04-25 12:10:00 UTC
Subject: re: Bob C: Albinism, Depigmentation, and Domestication
             Ok I read Bob's post at least a couple times, and while I think I 
understand albinism pretty well, I'm a bit befuddled on the difference 
between the expression of the Star Gene and Waardenburg's Syndrome.
On the FML a while ago, there was a discussion of Waardenburg's and 
associated problems, such as deafness, and other possible related health 
problems. Some suggested that breeding for "fancy" colors such as blazes 
and pandas was increasing the incidence of these health problems. There 
were further suggestions that shows should not encourage these colorations 
and that breeders should stop breeding for them.
But if blazes and pandas are expressions of the Star Gene, which is 
naturally selected for by domestication, is this not an impossible task? 
Can one deselect for one (blazes) without deselecting the other 
(domesticity)?
It seems to me from what admittly little reading I've done, that as 
recently as early last century (ie the 1900s), such color markings were 
very rare. Ferrets were either sable (polecat colored) or albino. Only in 
recent decades, when ferrets became popular as pets, did the color 
variations with white markings we know today become prevalent.
So I guess I'm asking: What is the difference between Waardenburg and Star 
Gene? Can you reduce the prevalence of one without effecting the other?
Linda Iroff
Oberlin OH