From:
Cheryl & Steve
Date: 2001-09-18 16:05:00 UTC
Subject: [Ferret-Health-list] Re: melatonin
Hi Mike,
I meant to say it the way you did, lol. Thanks for the
clarification Mike.
Cheryl & Steve
----- Original Message -----
From: Mike Janke
To: Ferret-Health-list@yahoogroups.com
Sent: Tuesday, September 18, 2001 1:18 PM
--- In Ferret-Health-list@y..., "Cheryl & Steve"
<email@t...> wrote:
>... Lupron is a synthetic form of Melatonin...
I'm not a pharmacist, doctor, biologist or have any medical
training
in any way, so if I don't have this quite right, I hope
someone will
straighten this out.
The hypothalamus releases GnRH in short pulses which
stimulates the
pituitary to release LH and FSH. These are what, in turn,
stimulate
the adrenals to release high levels of sex hormones which in
turn
causes the adrenal symptoms we see.
As I understand it, Lupron is not a sythetic form of
Melatonin, but
is a synthetic form of GnRH (Gonadotropin release hormone)
while
Melatonin inhibits GnRH production. Since it sounds like
they do the
opposite thing, one wonders how they each accomplish the
same goal.
The way I understand it, Lupron performs its magic by
supplying
relatively high, constant doses of GnRH to the pituitary.
The
pituitary becomes desensitized to this constant high level
of GnRH
and ceases production of two other hormones LH and FSH.
These are
hormones that stimulate the adrenals into releasing sex
hormones.
Melatonin, on the other hand, inhibits GnRH, which has the
same
effect on the pituitary, though by a different means. No
GnRH being
delivered to the pituitary means the pituitary stops
producing LH and
FSH.
mike
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