From:
Bruce Williams, DVM
Date: 2001-10-01 12:35:00 UTC
Subject: Re: Curious on Pathology Test
--- In Ferret-Health-list@y..., Vex@n... wrote:
>
>
>
> With these Pathology tests there are question marks and if's so if
> you can
> please give me your insight to possiblities please and Thank you
>
> Test Name Normal Out of Range Units Reference
Range
>
> History: Blood taken with the ferret awake. Diarrhea for 5 weeks,
> seems nauseous, as well vomit after eating, can stop if distracted
> with activity. Other ferrets had diarrhea but improved after 1 week
> on Chloramphememiol? No improvement.
>
> General Panel
> cbc with differential
>
> White cell cnt 2.3L 10.9/L 4.0-18.2
> CD-NEUTR 0.99 10e9/L
> CD-LYMPHS 1.000 10e9/L
> CD-MONOCYTES 0.129 10e9/L
> CD-EOSINOPHILS 0.111 10e9/L
> CD-BASOPHILS 0.035 10E9/l
> MORHOLOGY T
>
> -This is an automated differential, all absolute numbers are in SI
> units.
> -Platelet numbers are adequate
> -Platelets clumped
> -Rbc morphology normal
> -Pathologist to review
> -Variabilility in platelet size apparent
> -Few stimulated lymphocytes present.
>
> Red cell cnt 13.10 H 10.12/l 6.5-9.8
> Hemoglobin 201 H g/l 126-180
> Hematocrit 0.581 H l/l 0.420-0.550
> Mean Corp Vol. 44 fl 42-56
> Mean Corp Hemo-
> Globin 15.4 pg 13.0-16.0
> Mean Corp Hemo-
> Globin conc 347 g/l 300-370
> RDW 18.3
> Platelet Vol. ---- fl
> Chemistry screen ....
> Glucose 4.0 mmol/l 3.0-7.2
> Blood urea Nitrogen 8.3 mmol/l 5.9-14.0
> Creatinine 78 umol/l 75-156
> Bun/cr Ratio 27
> Sodium 146 mmol/l 140-158
> Potassium 3.9 L mmol/l 4.0-5.7
> Na/K Ratio 37
> Calcium 2.22 L mmol/l 2.31-2.70
> Phosphorus 1.13 mmol/l 0.92-2.15
>
> Total protein 58 g/l 50-74
> Albumin 35 g/l 25-40
> Globulin 23 L g/l 27-44
> Albumin/Globulin Ratio 1.5 H 0.4-1.0
> Bilirubin total 1 umol/l 0-10
> Alkaline Phosphatase 142 H iu/l 20-110
> Sgpt (alt) 378 H iu/l 87-340
> Gamma gt 7 mmol/l 4-25
> Chloride 110 mmol/l 110-118
> Carbon Dioxide 23 mmol/l 18-26
> Calculated
> Osmolality 291.1 mmol/l
> Anion Gap 17 07-19
> Creatine Phosphokinase 762 H iu/l 35-245
> Sgot (ast) unknown
>
> **Preliminary** Smear revealed only depris - no organisms
> Date/Time 08/28/01
11:04
> No growth present after 72 hours.
>
> SALMONELLA CHECK CONTINUE
>
> COMMENT:TO15
>
> LEUOPENIA, WITH NEUTROPENIA, VACCINATION HISTORY? PARVO?
> HEMOCONCENTRATION/SPLENIC CONTRACTION LOW K LOSS, GI? INCREASES ALP
> ALT? LIVER DISEASE? CHOLANGIOHEPATITIS, INCREASED CK? MUSCLE?
> CONCERN ALSO RE SERSE BUT GLUCOSE IS OK.
>
> I just would like other options and opions to this test and
> see if they are on the right track. Or if this has been seen before
> perhaps in the past. Skittles is doing better we think he just got
> over ECE and this can explain some of the abnormalities. I did the
> ultra sound and the only concern would be the left adrenal but even
> then the said it could be something to look at later down the raod
> not a major concern at this time. He does have good stool one day
and
> then green slime or seedy the next and then back to the norm.
> Although I just would like another opion on this test cause they
said
> it was liver failure and Skittles is doing fine now.
>
> Considering that is a good chance that it was ECE is there another
> test we could have done to confirm this or is it just look at the
> signs and symptoms? Vex
Well, to start - it's not liver failure - not even close. The mild
elevation in hepatic enzymes (SGPT and alk phos) are more indicative
of dietary irregularity and mobilization of fat to the liver -
nothing more. Note the normal bilirubin -
The leukopenia is mild at best, and does not indicate inflammatory
disease here. If there was a marked chronic inflamamtory response,
such as would be seen with cholangiohepatitis (which needs a biopsy
for diagnosis) there should also be a concomitant elevation in
globulins, which is not seen here.
Ferrets do not have an intestinal parvovirus like dogs, so that
interpretation is not valid.
The hemoconcentration is only mild at best, and I think that on
retest, it could just as easily be normal. CPK is not specific in
ferrets, and I usually don't pay a lot of attention to it, unless it
is extremely high (which it is not here.)
With kindest regards,
Bruce Williams, DVM