From:
elnrrgby1@aol.com
Date: 2001-11-06 18:34:00 UTC
Subject: Final Report- Sarcoma; Malignant Fibrous Histiocytoma
I just got a copy of the final pathology report this evening
and figured I would post the results for anyone interested.
Dr. Williams- I sent the remaining tissue samples off today,
so you should have them in a few days. Thank you again for
helping!!
Description/Intreptation:
30020
The submitted sections of ferret (Mustela putoris furo) spleen
are of excellent diagnostic quality. These contain the
primary alteration of sarcoma. The splenic parenchyma is
replaced and distorted by multiple proliferative,
infiltrative, poorly demarcated, densely cellular,
non-encapsulated malignant neoplastic masses. The neoplastic
cells are arranged in sheets and ill-defined bundles and
cords. These consist of round to spindle to large bizarre
cells. The round individualized cells have low to moderate
amounts of eosinophilic cytoplasm and round to oval to clefted
coarsely stippled nuclei. At times these cells exhibit bi-
and multi-nucleation. These cells are similar to histiocytic
cells and at times are also similar to lymphoid cells. The
spindle cells are not as prominent as the individualized cells
or the large bizarre cells. These have mild to moderate
amounts of eosinophilic cytoplasm. The large bizarre cells
have abundant eosinophilic cytoplasm with rarely seen
eosinophilic perinuclear inclusions. Nuclei are very large,
single to multiple, variably-shaped and bizarre with coarsely
stippled to vesicular chromatin and indistinct to prominent
large nuclei. The degree of anisokaryosis and anisocytosis is
marked. The mitotic rate appears low. Other areas of the
spleen exhibit extramedullary hematopoiesis and lymphoid
hyperplasia. Multifocal areas of hemorrhage with hemosiderin
laden macrophages are noted. There are multifocal small areas
of extracellular eosinophilic material deposition. This
material may be fibrin of amyloid. No etiologic agents are
seen.
Spleen: Sarcoma, most consistent with malignant fibrous
histiocytoma (giant cell variant) with extramedullary
hematopoiesis, hemorrhage and possible minimal amyloid
deposition.
Comment: The morphology of this neoplasm is remarkable. The
predominance of the individualized round cells, the
spindle-shaped cell and the giant cells varies depending on
the area of the spleen. In a few areas the individualized
cells would be hard to differentiate from lymphoid cells.
Overall the morphology is most consistent with malignant
fibrous histiocytoma (giant cell variant). Prognosis is poor.
The presence of the possible amyloid is likely of no clinical
significance and is likely secondary to the main pathologic
process.
Thanks,
Stacia