From:
AFERRETVET@cs.com
Date: 2003-11-30 01:58:38 UTC
Subject: Re: Lupron- long term use
To: ferrethealth@smartgroups.com
Message-ID: <be.334f11.2cfaa8ce@cs.com>
Hi Girbabe,
Interesting question. It sounds like you are
wondering if Lupron caused your ferret to get
insulinoma and lymphosarcoma, and the
answer is NO.
Unfortunately adrenal gland disease, insulinoma, and
lymphoma/lymphosarcoma are the 3 most common
cancers that ferrets get. Your ferret had all 3, and that
is not uncommon.
In rats giving very high doses of Lupron (0.6 mg to 4mg/kg)
daily for 2 years there was an increase in pituitary adenomas
and hyperplasia. In mice giving very high doses (up to 60 mg/kg)
daily for 2 years there was no pituitary problems. In humans
with high doses (10 mg/day) for 3 years or 20 mg/day for
2 years, there was no pituitary abnormalities. I have been using
Lupron depot (once a month version) for almost 6 years now with
no pituitary problems that I know of. No reason to be afraid of
Lupron for medical treatment of adrenal gland disease.
Hope that helps,
Jerry Murray, DVM
PS Lupron is not that new on the human side. It has been
used since 1988.
End of ferrethealth Digest
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