From:
"Sue Liszewski"
Date: 2004-08-15 18:13:19 UTC
Subject: RE: [ferrethealth] Need help with histopathology report
To: ferrethealth@smartgroups.com
Message-ID: <BAY15-F2274kd45M4ky0000729d@hotmail.com>
Early lymphoma, yes hyperplasia of the adrenal gland is what we see syptoms
with and if one is very actice the other temporarily atrophies then when the
more active is removed it comes back up. There is all some compression of
the vessels in the liver and is responsible for hypertension in the liver
sort of like high blood pressure so the liver has trouble. Can see fat
deposition with adrenal, with lymphoma, etc. I agree all of the latter
stuff was not responsible for the death it was the kidney problem. Hope
this helps a bit and doesn't confuse you more.
Dr. Sue
>From: "Ulrike" <ferretlove_uk@yahoo.co.uk>
>Reply-To: ferrethealth@smartgroups.com
>To: "Ferrethealth" <ferrethealth@smartgroups.com>
>Subject: [ferrethealth] Need help with histopathology report
>Date: Sun, 15 Aug 2004 16:49:52 +0100 (GMT Standard Time)
>
>Baby was 7-8 years old, spayed at 1-2 years old, and I had her put to sleep
>at the end of July. We thought that she had lymphoma but really she had
>CRF
> Her lymph nodes were covered with a lot of fat. At the end of last year
>she looked like she had adrenal disease, she'd lost a lot of her coat. We
>did an abdominal exploratory but the adrenal glands looked fine so we left
>them. Baby grew her coat back after surgery. The report now said there
>was
>adrenal hyperplasia (the adrenal gland was still very small though and my
>vet only found the left one and could not find the right, could it have
>atrophied?), is that what adrenal disease is and does that cause clinical
>signs? She had a lot of fat in her abdomen and chest cavity, what could
>have caused that? The adrenal hyperplasia? She had been on pred for a
>month before her death. Could pred cause this amount of fat? If anybody
>wants to see pictures, they're here:
>
>www.ferretlove.co.uk/babypm.htm
>
>I would just like to know what the report says. My vet explained it to me
>quickly but still using veterinary terms, I think she thinks I understand
>all the vet language... ;-)
>
>
>
>HISTORY
>
>Lethargy, inappetence, PD, abdominal distension, Splenomegaly not verified
>on post mortem.
>
>Chronic Renal Failure
>
>Prognosis Not Applicable
>
>Histologic findings:
>
>Kidney (slide 1, 2 sections): Several wdge-shaped areas in the renal cortex
>with a depressed capsular surface contain interstitial fibrosis, the
>tubules
>are either lost or distended and with attenuated epithelium, sometimes
>filled with hypereosinophilic material (protein casts). In one area, the
>tubular epithelium is completely lost and replaced by basophilic
>mineralized
>material. Glomeruli in these areas are absent or have a very thickened
>mesangium and shrunken tuft with variable degrees of fibrosis (glomerular
>sclerosis). Similar changes, i.e. thickened mesangium and some increase in
>cellularity are present in many other glomeruli across the sections
>examined
> In some glomeruli, the epithelium of Bowmans capsule is separated from
>the
>basement membrane by accumulation of palely eosinophilic amorphous material
>(Congo Red negative-not amyloid). The interstitium of the renal medulla has
>multifocal to coalescent fibroplasias (fibrosis) and compression or loss of
>collecting ducts.
>
>Lymph node (slide 1, 1 section): There is a uniform population of medium
>size lymphocytes without clear germinal centers in the cortex and
>paracortex
> The medullary sinuses are greatly distended by clear edema fluid. Several
>clusters of plasma cells are present in the septa. Within the sinuses, many
>macrophages are completely surrounded by erythrocytes that have attached to
>the outer surface of their cellular membrane.
>
>Adrenal gland (slide 1, 1 section): A focal proliferation of cortical cells
>is present outside the adrenal capsule.
>
>Liver (slide 2, 1 section): The surface contour is irregularly pitted.
>There
>are several clusters of oval cell proliferation with frequent
>differentiation towards small bile ducts present in the lobular parenchyma
>and, less often, in portal zones. Several small arterioles are also present
>within the lobular parenchyma (microvascular proliferation). Minimal areas
>of hepatocellular necrosis with some neutrophils are present.
>
>No significant lesions are present in the pancreas.
>
>Comment:
>
>The changes in the kidneys of this ferret are marked to severe and
>characteristic of chronic renal failure (CRF). CRF very possibly caused the
>clinical signs as glomerular injury is accompanied by protein loss and
>polyuria, which would have resulted in polydipsia. The cause of CRF is
>often
>difficult to pinpoint. Chronic inflammation with deposition of
>antigen-antibody complexes in the glomerular basement membranes is often
>associated with CRF development.
>The liver had a mild bile duct hyperplasia and a multifocal microvascular
>proliferation. Microvascular proliferation in adult animals generally
>indicates some form of portal hypertension that stimulates the formation of
>alternative vessels to relief the pressure.
>The appearance of the lymph node examined suggests an early stage of
>lymphosarcoma. There is cortical adrenal hyperplasia, not uncommon in
>ferrets.
>
>
>
>
>
>
>
>
>--
>If you want to share pictures, use the calendar, or start a vote
>visit http://www.smartgroups.com/groups/ferrethealth
>
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