From:
pjdutche@email.unc.edu
Date: 2004-10-22 14:56:31 UTC
Subject: RE: Cutaneous Lymphoma - pics of Nana''s foot
To: ferrethealth@smartgroups.com
Message-ID: <5216819.1098456991052.JavaMail.root@thallium.smartgroups.com>
I should have mentioned that we are going to treat this with Isotretinoin, =
Omega-3 fatty acids, and oatmeal-colloidal baths. She is already on pred f=
or insulinoma.
An article in JAVMA (vol 209, no 8) from October 1996 discusses a case of c=
utaneous lymphoma in a ferret, and it responded pretty well to oral isotret=
inoin and died because pre-existing kidney disease worsened dramatically, p=
ossibly from steroid use. Pubmed cite below.
-Pam S.
J Am Vet Med Assoc. 1996 Oct 15;209(8):1441-4. =
Cutaneous epitheliotropic lymphoma in a ferret.
Rosenbaum MR, Affolter VK, Usborne AL, Beeber NL.
Department of Clinical Studies, School of Veterinary Medicine, University o=
f Pennsylvania, Philadelphia 19104-6010, USA.
An 8-year-old spayed female ferret was examined for diffuse generalized alo=
pecia, erythema, erosions, crusts, and ulcerated plaques that were nonrespo=
nsive to long-term administration of corticosteroids. Cutaneous epitheliotr=
opic lymphoma was diagnosed on the basis of histologic examination of skin =
biopsy specimens. Neoplastic cells were determined to be of T-lymphocytic o=
rigin by results of immunohistochemical staining with a rabbit anti-CD3 mon=
oclonal antibody. Additional laboratory abnormalities detected included ane=
mia, azotemia, isosthenuria, pyuria, and bacteriuria. Treatment included is=
otretinoin and amoxicillin trihydrate plus clavulanate potassium administer=
ed orally, and oatmeal-based shampoos. Isotretinoin was tolerated well and =
cutaneous lesions resolved after 60 days of treatment, but pretreatment azo=
temia worsened and the ferret was euthanatized. Necropsy revealed cutaneous=
epitheliotropic lymphoma, pyelonephritis, and interstitial nephritis. Rena=
l disease most likely was caused by immunosuppression secondary to chronic =
treatment with corticosteroids and aging. Isotretinoin, although not curati=
ve, may be useful for the palliative treatment of cutaneous epitheliotropic=
lymphoma in ferrets.
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