From:
sukiec@optonline.net
Date: 2005-02-05 19:31:39 UTC
Subject: RE: Captopril instead of Enalapril?
To: ferrethealth@smartgroups.com
Message-ID: <3091842.1107631899442.JavaMail.root@thallium.smartgroups.com>
A search found these:
In _Essentials of Ferrets, a guide for practitioners_ page 29 Dr Purcell wr=
ites:
>Captopril
>1.6 mg/kg (1/8 of tablet)
>q 48h PO =
Vasodilator. This is the starting dose. Eventually, increase frequency to=
q 12 - 24 h. Can cause lethargy
http://www.vetsoftware.com/acvc2002-hess2.htm
including:
Enalopril (0.5 mg/kg PO q 48h) or captopril=A0 (1/8th of a
12.5 mg tablet PO q 48h) can be used to decrease afterload. If the
ferret becomes lethargic from hypotension, the dose should be
decreased to once every third day.
http://www.ferretnews.org/cardiomyopathy.html
including
>Treatment of cardiomyopathy involves medication to
>remove accumulated fluid, such as the diuretic furosemide.
>Vasodilators to modulate blood pressure are also often
>used, such as Nitrol or captopril. Digitalis derivatives can be
>helpful to increase the strength and efficiency of the failing heart.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=3DRetrieve&db=3DPubMed&li=
st_uids=3D7982459&dopt=3DAbstract
>Eur J Pharmacol. 1994 Jul 11;259(3):309-13.
Effects of bradykinin receptor agonists, and captopril and thiorphan
>in ferret isolated trachea: evidence for bradykinin generation in vitro.
>Farmer SG, Broom T, DeSiato MA.
>Zeneca Pharmaceuticals Group, Wilmington, DE 19897-2300.
>Bradykinin B2 receptor agonists, but not a B1 receptor agonist, were
>potent spasmogens of ferret isolated trachea...
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=3DRetrieve&db=3DPubMed&li=
st_uids=3D3279179&dopt=3DAbstract
Looks to be a similar subject
http://circ.ahajournals.org/cgi/content/full/92/9/2660
is on L ventricular relaxing. The study was on cavies but in google there =
is a ferret mention, so perhaps there is some info for anyone who is intere=
sted.
Dog and cat dosing (but not ferret for this med) are in:
http://info.med.yale.edu/yarc/vcs/miscellaneous1.htm
This drug was developed from pit viper studies. Mark Plotkin is someone I =
spent jungle time with in Suriname back in '78 when we were both students s=
o it was weird but understandable seeing this particular old friend show up=
in the search:
http://www.principalvoices.com/voices/mark-plotkin-white-paper.html
=
=