Message Number: SG13345 | New FHL Archives SearchFrom: sukiec@optonline.net
Date: Tue, 5 Apr 2005 20:52:37 +0100 (BST)
To: ferrethealth@smartgroups.com
Subject: RE: air cleaners: making sure they don''t damage lungs
Message-ID: <6021182.1112730757995.JavaMail.root@thallium.smartgroups.com>
Searching on
ozone ferret
I find a LOT of URLs including
http://ajrccm.atsjournals.org/cgi/content/abstract/162/3/1152
> Am. J. Respir. Crit. Care Med., Volume 162, Number 3, September 2000, 115=
2-1156
=
>Ozone-induced Epithelial Injury in the Ferret Is Similar to Nonhuman Prima=
tes =
>ANJA STERNER-KOCK, MARTIN KOCK, RUEDI BRAUN, and DALLAS=A0M. HYDE =
>Department of Anatomy, Physiology and Cell Biology and California Regional=
Primate Research Center, University of California, >Davis, California =
>Extrapolation to humans from rodent ozone exposure is limited by the anato=
mic differences between the species. Ferrets have similar >pulmonary struct=
ures to humans, with well developed respiratory bronchioles and submucosal =
glands. We exposed adult ferrets, >monkeys, and rats to 1=A0ppm ozone (O3) =
or filtered air for 8=A0h followed by 1=A0h in filtered air. Bronchoalveola=
r lavage (BAL) analysis, >histopathology, and confocal microscopy were used=
to evaluate ozone-induced epithelial injury and inflammation. BAL showed >=
significantly increased numbers of neutrophils in ozone-exposed as compared=
with filtered air ferrets, monkeys, and rats. However, >there were 3-=A0to=
4-fold more neutrophils in monkeys and ferrets per milliliter of BAL than =
in rats. Ozone-exposed lungs showed a >severe, acute infiltration of neutro=
phils
...
>We conclude that acute ozone exposure in ferrets induce severe epithelial =
necrosis and inflammation, results in similar epithelial injury >compared w=
ith monkeys, and represents a better model of humans than rodents.
The pdf download is available.
---
In 1998, volume 9, no. 4 in this AFA URL:
http://www.ferret.org/newsletter/AFRarch96_98.htm
Freddie Ann Hoffman, a pediatrician, has an article on the risks of ozone
---
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=3DRetrieve&db=3DPubMed&li=
st_uids=3D1855492&dopt=3DAbstract
>Environ Res. 1991 Jun;55(1):79-90.
>Effects of ozone on the cholinergic secretory responsiveness of ferret tra=
cheal glands.
>McBride RK, Oberdoerster G, Marin MG.
>Department of Medicine, University of Rochester School of Medicine and Den=
tistry, New York 14642-8692.
>Oxidant air pollutants exacerbate several pulmonary diseases. Inhalation o=
f ozone has been shown to induce airway smooth muscle >hyperresponsiveness.=
Oxidant injury could also affect airway secretory mechanisms
...
>These experiments suggest that oxidant injury not only increases basal sec=
retion of respiratory glycoconjugates but also increases >tracheal gland se=
nsitivity to a cholinergic agonist.
then hitting =
"Related Articles" there pulls up 129 articles, not all of them work in fer=
rets but those are included in the ones listed.
=
=
Send comments to Pam at pjdutche@email.unc.edu. Please note that this address is only useful for questions about the FHL archive. Questions about ferret health, or those intended for the FHL, should be sent to the Ferret Health List.