From:
Sukie Crandall
Date: 2005-07-02 17:54:46 UTC
Subject: maybe good news for future ferrets prone to ulcers and others
To: ferrethealth@smartgroups.com
Message-id: <1B26CBB8-B288-48CC-BFC3-6FBF962CCD13@mac.com>
Maybe also something like this might help with ferrets who have
diseases that worsen due to extreme inflammatory response (cytokine
storm) or complications associated with inflammatory response such as
ADV or DIM.
For those who get Science News or Proceedings of the National Academy
of Sciences, or whose libraries do:
SN: Week of July 2, 2005; Vol. 168, No. 1 , p. 3
>Bruce D. Hammock, a biochemist at the University of California,
>Davis, and his colleagues now report that two experimental
>drugs shield lab mice from extreme inflammation.
>...troublesome enzyme, called soluble epoxide hydrolase,
>degrades natural inflammation inhibitors known as
>epoxyeicosatrienoic acids (EETs). The experimental drugs in
>the new study bind to and inactivate the enzyme.
>...injected mice with molecules from the surface of Escherichia coli
>bacteria... provoke a severe inflammatory response.
>injection of one of the two enzyme-inhibiting drugs or of an inert
>substance. Mice getting the drugs survived, whereas within 4 days,
>plummeting blood pressure had killed all...that received placebo
shots...
>unchecked inflammation showed extensive kidney and liver damage.
>...process similar to that caused by blood infection, or sepsis...
>... new drugs, which are currently called AUDA-BE and Compound 950,
>will be tested as oral medicines in people within 18 months.
>"We envision these as general anti-inflammatory drugs," Hammock says.
>But the new drugs may also counter sepsis, he says.
Schmelzer, K.R. . . . and B.D. Hammock. In press. Soluble epoxide
hydrolase is a therapeutic target for acute inflammation. Proceedings
of the National Academy of Sciences. Available at http://www.pnas.org/
cgi/doi/10.1073/pnas.0503279102.
Further readings attached to the Science News Article
I will be sending further info on some people involved in or
associated with research into DIM or ADV in case this approach MIGHT
have promise for those.
-- Sukie (not a vet)
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