From:
sukiec@optonline.net
Date: 2005-08-25 19:33:59 UTC
Subject: RE: Generic Lupron Question
To: ferrethealth@smartgroups.com
Message-ID: <2194668.1124998439537.JavaMail.root@thallium.smartgroups.com>
I can't recall being able to feel anything under the skin with the depot. I think the time release is achieved at a smaller level since it is a fluid.
Mike told me how to find the post and here it is:
http://fhl.sonic-weasel.org/browse.php?msg=SG8652
The author, Dr. John Hines, has a PhD in pharmacology and has studied Lupron, so you couldn't ask for someone who is more expert.
It includes:
"... if the Lupron is of the type that all enters the bloodstream in 24
hrs., (24 hr. Lupron) what you get is a few hours of high pituitary
activity followed by only several HOURS of inactivity (desensitized).
Then the 24 hr. Lupron is gone shortly thereafter, and the pituitary
RE-sensitizes and LH release to the natural GnRH resumes probably in a
day or so. If the ferret is only getting the 24hr. shot once a month,
it's useless. In fact, the use of the 24 hr. Lupron probably makes the
adrenal disease worse because you don't get much therapeutic effect, but
you are still getting that initial high pituitary activity when the
Lupron is first administered. This initial burst of pituitary activity
is of little consequence when it is followed by cessation of pituitary
activity. But, with the 24 hr. Lupron, you get only the initial burst
of pituitary high activity -- followed by normal pituitary activity.
It's like adding a splash of gasoline to a fire."
So, that is why the Lupron should be in depot form. Make sure to ask specifically for "Lupron Depot". Most vets already know this, but checking never hurts as long as a person asks politely.
The depots come in different strengths and in 1 month or 4 month depots at ferret sizes.
Hope that helps!