From:
sukiec@optonline.net
Date: 2005-09-08 02:49:24 UTC
Subject: Re: [ferrethealth] Suprelorin - Europe
To: ferrethealth@smartgroups.com
Message-ID: <7486527.1126147764787.JavaMail.root@thallium.smartgroups.com>
Author wrote:
> It did say anything about it being used for ferrets.
> The doses were for dogs. Is there anything that states
> that it could be used for ferrets?
> Northern
There have been three studies on its use in ferret for adrenal growths so f=
ar, and I have heard of another on-going. The results were quite like thos=
e for Lupron in what I have read so far.
See:
http://fhl.sonic-weasel.org/browse.php?msg=3DSG10790
which reads in part:
>Glad to hear you are interested in Suprelorin (deslorelin acetate) =
>implants. In addition to Dr Wagner's study with adrenal ferrets, =
>there was a study done at the vet school in Budapest, Hungary =
>with intact ferrets. Worked well in both studies. They lasted for =
>8-20 months in the adrenal ferrets and 18+ months in the intact =
>ferrets (if I remember correctly what Dr Huszenicza said). =
>I would certainly use them if they were available here in the USA. =
>Jerry Murray, DVM =
>Dallas, Texas =
Here is an example:
http://www.vet.utk.edu/faculty/oliver.shtml
>Wagner, R.A., C.A. Piche, W. Jochle and J.W. Oliver. Clinical observation=
s and >endocrine response to treatment of adrenal cortical disease in ferre=
ts with GnRH >(deslorelin acetate) implants. Am. J. Vet. Res., In press.
Abstract:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=3DRetrieve&db=3Dpubmed&do=
pt=3DAbstract&list_uids=3D15934621&query_hl=3D2
BEGIN PARTIAL QUOTE
Am J Vet Res. 2005 May;66(5):910-4. Related Articles, Links
Clinical and endocrine responses to treatment with deslorelin acetate impla=
nts in ferrets with adrenocortical disease.
Wagner RA, Piche CA, Jochle W, Oliver JW.
Division of Laboratory Animal Resources, 3500 Terrace St, S1049 BST, Univer=
sity of Pittsburgh, Pittsburgh, PA 15261, USA.
OBJECTIVE: To evaluate the clinical and endocrine responses of ferrets with=
adrenocortical disease (ACD) to treatment with a slow-release implant of d=
eslorelin acetate. ANIMALS: 15 ferrets with ACD. PROCEDURE: Ferrets were tr=
eated SC with a single slow-release, 3-mg implant of deslorelin acetate. Pl=
asma estradiol, androstenedione, and 17-hydroxyprogesterone concentrations =
were measured before and after treatment and at relapse of clinical signs; =
at that time, the adrenal glands were grossly or ultrasonographically measu=
red and affected glands that were surgically removed were examined histolog=
ically. RESULTS: Compared with findings before deslorelin treatment, vulvar=
swelling, pruritus, sexual behaviors, and aggression were significantly de=
creased or eliminated within 14 days of implantation; hair regrowth was evi=
dent 4 to 6 weeks after treatment. Within 1 month of treatment, plasma horm=
one concentrations significantly decreased and remained decreased until cli=
nical relapse. Mean time to recurrence of clinical signs was 13.7 +/- 3.5 m=
onths (range, 8.5 to 20.5 months). In 5 ferrets, large palpable tumors deve=
loped within 2 months of clinical relapse; 3 of these ferrets were euthanat=
ized because of adrenal gland tumor metastasis to the liver or tumor necros=
is...
END PARTIAL QUOTE
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