From:
sukiec@optonline.net
Date: 2005-10-19 21:27:35 UTC
Subject: Re: [ferrethealth] I have a question about esophageal pain nerves and about MegaE
To: ferrethealth@smartgroups.com
There are studies in other species showing increased rated of trouble swallowing (dysphagia -- hope I spelled that right) when some neural crest genetic variations are present, so I think that your rate question is a good one.
Trouble swallowing came up on Ferret-Genetics months back (last year? early this year?) and some studies are cited there, and I suspect that Pubmed may be a useful source, too.
For example in the abstract of
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11984512&query_hl=1>
>Gastroenterology. 2002 May;122(5):1258-63. Related Articles, Links
>Abnormal esophageal motility in children with congenital central hypoventilation >syndrome.
>Faure C, Viarme F, Cargill G, Navarro J, Gaultier C, Trang H.
notice (esp. the start of the second sentence):
>Congenital central hypoventilation syndrome, an unexplained disorder of the >central control of breathing that may reflect widespread dysfunction of brainstem >structures, is regarded as a form of neuro cristopathy. Because swallowing->induced peristalsis is centrally controlled and depends on neural crest-derived >esophageal innervation, we looked for esophageal dysmotility in patients with >congenital central hypoventilation syndrome.
Here is an unusual dysphagia with ultimately neural crest related cause:
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10744802&query_hl=1>
>Can J Cardiol. 2000 Mar;16(3):383-5. Related Articles, Links
>A left atrial paraganglioma patient presenting with compressive dysphagia.
>Tekin UN, Khan IA, Singh N, Nair VM, Vasavada BC, Sacchi TJ.
etc.
I just searched on
dysphagia "neural crest"
in Pub Med for those and more.
Megaesophagus "neural crest"
did not bring anything up.
Nor did
achalasia "neural crest".
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