From:
Sukie Crandall
Date: 2005-10-31 18:16:40 UTC
Subject: [ferrethealth] sevo article
To: ferrethealth@smartgroups.com
> Am J Vet Res. 2004 May;65(5):653-8.
> Related Articles, Links
>
> Effect of sevoflurane on hemodynamic and cardiac energetic
> parameters in ferrets.
>
> MacPhail CM, Monnet E, Gaynor JS, Perini A.
>
> Department of Clinical Sciences, College of Veterinary Medicine and
> Biomedical Sciences, Colorado State University, Fort Collins, CO
> 80523-1620, USA.
>
> OBJECTIVE: To determine the effect of sevoflurane on cardiac
> energetic and hemodynamic parameters in ferrets. ANIMALS: 7 healthy
> domesticated ferrets. PROCEDURE: Sevoflurane was used as the sole
> anesthetic agent for general anesthesia in ferrets. Standard
> midline laparotomy and median sternotomy were performed to permit
> instrumentation. Myocardial blood flow was determined by use of
> colored microsphere technology. Measurements and blood samples were
> obtained at 1.25%, 2.5%, and 3.75% expired concentration of
> sevoflurane. RESULTS: A dose-dependent decrease in arterial blood
> pressure, left ventricular pressure, systemic vascular resistance,
> aortic flow, and dp/dt (an index of contractility) was detected as
> expired concentration of sevoflurane increased. Heart rate, central
> venous pressure, coronary vascular resistance, myocardial oxygen
> extraction ratio, and tau (the time constant of relaxation) were
> unchanged. Cardiac external work decreased, as did myocardial
> oxygen consumption, causing increased cardiac efficiency at higher
> concentrations of sevoflurane. CONCLUSIONS AND CLINICAL RELEVANCE:
> Sevoflurane caused minimal and predictable cardiovascular effects
> in ferrets without increasing myocardial metabolic demands. Data
> obtained from this study have not been previously reported for a
> species that is being commonly used in cardiovascular research.
> These findings also support use of sevoflurane as a safe inhalant
> anesthetic in ferrets for clinical and research settings.
-- Sukie (not a vet)
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