From:
sukiec@optonline.net
Date: 2005-11-23 16:44:43 UTC
Subject: [ferrethealth] Doing piece by piece [Part Administration and part melatonin post]
To: ferrethealth@smartgroups.com
Twice now in several minutes I have sent a message in to the FHL using separate addresses only to have the content stripped out, so as a co-moderator here I am curious to see if the web mail function is working because the direct mail one for moderators may be busted.
I will include PART of the failed melatonin message. If it works I will in later webposts put other melatonin study info (ADV, lymphoma, etc.). Forgive the quote marks from working from one of my own forwards.
> A press release in Eurekalert points to something on which the U.S.
> veterinary community was faster on the uptake than the U.S. medical
> community, though it has not be applied as widely as perhaps it can
> be.
>
> In a metanalysis of multiple studies found a 34% reduction in
> death rate at one year among the humans with a range of solid
> tumors when large doses of melatonin were used.
>
> I wonder what other tumors in ferrets besides adrenal ones may work
> out better with melatonin as part of the treatment?
>
> Melatonin is a natural product which the pineal gland produces in
> response to darkness. Light exposure decreases melatonin
> production, even a night light. In fact, I recall reading a while
> back of a study starting on whether NOT using night lights would
> improve survival for human childhood leukemia patients, but have
> not run into anything on that, yet, but in looking for that I found
> some potentially intriguing studies that are mentioned under the J.
> Pineal Res. article.
>
> START QUOTE
>
> Journal of Pineal Research
> Volume 39 Issue 4 Page 360 - November 2005
> doi:10.1111/j.1600-079X.2005.00258.x
>
>
> Melatonin in the treatment of cancer: a systematic review of
> randomized controlled trials and meta-analysis
> Edward Mills1, Ping Wu2,3, Dugald Seely3,4 and Gordon Guyatt1
> Abstract: Most observational studies show an association between
> melatonin and cancer in humans. We conducted a systematic review of
> randomized controlled trials (RCTs) of melatonin in solid tumor
> cancer patients and its effect on survival at 1 yr. With the aid of
> an information specialist, we searched 10 electronic databases from
> inception to October 2004. We included trials using melatonin as
> either sole treatment or as adjunct treatment. Prespecified
> criteria guided our assessment of trial quality. We conducted a
> meta-analysis using a random effects model. We included 10 RCTs
> published between 1992 and 2003 and included 643 patients. All
> trials included solid tumor cancers. All trials were conducted at
> the same hospital network, and were unblinded. Melatonin reduced
> the risk of death at 1 yr (relative risk: 0.66, 95% confidence
> interval: 0.590.73, I2 = 0%, heterogeneity P ? 0.56). Effects were
> consistent across melatonin dose, and type of cancer. No severe
> adverse events were reported. The substantial reduction in risk of
> death, low adverse events reported and low costs related to this
> intervention suggest great potential for melatonin in treating
> cancer. Confirming the efficacy and safety of melatonin in cancer
> treatment will require completion of blinded, independently
> conducted RCTs.
>
> END QUOTE
>
>
> Press release:
> http://www.eurekalert.org/pub_releases/2005-11/mudo-ttr112205.php
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