From:
sukiec@optonline.net
Date: 2005-11-23 16:54:07 UTC
Subject: [ferrethealth] RE: Doing piece by piece [Part Administration and part melatonin post]
To: ferrethealth@smartgroups.com
The web posting works, so I will remove the two empty posts and alert Smartgroups to that function problem.
Hopefully, approved posts will also work now that this glitch has begun.
---
> MORE (There are others so I will need to make time to read more
> widely if I can, BUT NOTE THE GENERAL STATEMENT BELOW since it
> should also have veterinary implications):
>
> START QUOTE
> Med Hypotheses. 2005;64(4):864-71.
> Related Articles, Links
>
>
> Could visible light contribute to the development of leukaemia and
> other cancers in children?
>
> Erren TC.
>
> Institute and Policlinic for Occupational and Social Medicine,
> School of Medicine and Dentistry, University of Cologne, Joseph-
> Stelzmann-Str. 9, 50924 Koln, Lindenthal, Germany. tim.erren@uni-
> koeln.de
>
> This paper suggests to rigorously test the hypothesis that there
> are causal links between visible light and the development of
> leukaemia and other cancers in children. Light can be considered as
> a candidate risk factor because it suppresses melatonin
> biosynthesis which may play a role in a series of anticancer
> defences. Indeed, melatonin may offer some protection against all
> "hallmarks of cancer" [i.e., self-sufficiency in growth signals;
> insensitivity to growth-inhibitory signals; evasion of programmed
> cell death (apoptosis); limitless replicative potential; sustained
> angiogenesis; tissue invasion and metastasis] recently suggested by
> Hanahan and Weinberg. Already ongoing investigations into the
> possible nexus of light, endocrine systems and the development of
> cancers will be further fueled by recent insights into
> photoreception and -- transduction, including the discovery of
> "novel" photoreceptors in the eye. Among a variety of different
> photosensory tasks, these receptors constitute crucial gates for
> light information from the environment which is employed for the
> temporal organization of our physiology and it has been proposed
> that chronodisruption, i.e., a significant disturbance of the
> coordination and thus order of biological rhythms, could contribute
> to the development of cancers. With regard to public health, the
> pervasive exposures to light -- at work and in homes -- imply that
> visible radiation could be a strong risk factor defined
> epidemiologically as a causal contributor to disease in a large
> proportion of cases. Importantly, if light were to be corroborated
> as a contributor to cancers in children, it would be amenable to
> manipulations with the perspective of reducing inherent risks
> significantly. In fact, it could be much easier -- and much more
> effective -- to reevaluate and modify lighting systems than to
> manipulate other possible determinants of the chronic processes of
> cancer such as genetic, nutritional or lifestyle factors.
>
> This article in PubMed may be of use to some, too, because of an
> interesting possible mechanism discussed (abstract available at
> PubMed):
>
> START QUOTE
> Henshaw DL, Reiter RJ.
> Do magnetic fields cause increased risk of childhood leukemia via
> melatonin disruption?
> Bioelectromagnetics. 2005;Suppl 7:S86-97.
> PMID: 16059923 [PubMed - in process]
> END QUOTE
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