From:
sukiec@optonline.net
Date: 2005-11-23 16:55:21 UTC
Subject: [ferrethealth] RE: Doing piece by piece [Part Administration and part melatonin post]
To: ferrethealth@smartgroups.com
> This is a veterinary study of melatonin reducing the impact of some
> viral diseases in animals. Note the ADV mention and more. Also,
> remember that some malignancies can have disease triggers:
>
> START QUOTE
>
> J Pineal Res. 2004 Mar;36(2):73-9.
> Related Articles, Links
>
> Melatonin and viral infections.
>
> Bonilla E, Valero N, Chacin-Bonilla L, Medina-Leendertz S.
>
> Instituto de Investigaciones Clinicas 'Dr. Americo Negrette',
> Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela.
> ebonillaro@yahoo.com
>
> The therapeutic effects of melatonin against viral infections, with
> emphasis on the Venezuelan equine encephalomyelitis (VEE), are
> reviewed. Melatonin has been shown to prevent paralysis and death
> in mice infected with the encephalomyocarditis virus and to
> decrease viremia. Melatonin also postpones the onset of the disease
> produced by Semliki Forest virus inoculation and reduces the
> mortality of West Nile virus-infected mice stressed by either
> isolation or dexamethasone injection. An increase in the host
> resistance to the virus via a peripheral immunostimulatory activity
> is considered responsible for these effects. It has also been
> demonstrated that melatonin protects some strains of mink against
> Aleutian disease, and prevents the reduction of B- and T-cells as
> well as Th1 cytokine secretion in mice infected with leukemia
> retrovirus. In VEE-infected mice, melatonin postpones the onset of
> the disease and death for several days and reduces the mortality
> rate. This protective effect seems to be due to the increase in the
> production of interleukin-1beta (IL-1beta), as 100% of the infected
> mice treated with melatonin die when IL-1beta is blocked with
> antimurine IL-1beta antibodies. Although melatonin administration
> raises serum levels of tumor necrosis factor-alpha (TNF-alpha) and
> interferon-gamma (IFN-gamma), the mortality observed in
> neutralization experiments with the corresponding anticytokine
> antibodies, suggests that neither TNF-alpha nor IFN-gamma are
> essential for the protective effect of melatonin on murine VEE
> virus infection. Melatonin treatment also enhances the efficiency
> of immunization against the VEE virus. Reactive oxygen species have
> been implicated in the dissemination of this virus, and their
> deleterious effects may be diminished by melatonin. This indole
> inhibits nitric oxide synthetase activity and it is a potent
> scavenger of nitric oxide, which also plays an important role in
> the spread of the VEE virus. In conclusion, the immunomodulatory,
> antioxidant, and neuroprotective effects of melatonin suggest that
> this indole must be considered as an additional therapeutic
> alternative to fight viral diseases.
>
> END QUOTE
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