From:
sukiec@optonline.net
Date: 2005-11-23 16:56:57 UTC
Subject: [ferrethealth] RE: Doing piece by piece [Part Administration and part melatonin post]
To: ferrethealth@smartgroups.com
> BTW, it has recently been found in humans that lymphoid cells also
> produce melatonin and that this plays a part in immune system
> regulation. (Found in this abstract which indicates that it may be
> useful when lymphoma is present):
>
> START QUOTE
> J Pineal Res. 2005 Nov;39(4):425-31.
> Related Articles, Links
>
>
> Melatonin provokes cell death in human B-lymphoma cells by
> mitochondrial-dependent apoptotic pathway activation.
>
> Trubiani O, Recchioni R, Moroni F, Pizzicannella J, Caputi S, Di
> Primio R.
>
> Dipartimento di Scienze Odontostomatologiche, Universita di Chieti-
> Pescara, Via dei Vestini, Chieti, Italy. trubiani@unich.it
>
> Apoptosis is an important cell suicide programme involved in
> physiological and pathological processes. Apoptosis can be induced
> in different ways depending on cell type and acquired signal.
> Melatonin, the major secretory product of the pineal gland,
> participates in many important physiological functions and displays
> a remarkable functional versatility exhibiting antioxidant,
> oncostatic, anti-aging, and immunomodulatory properties. Recently,
> it has been shown that, in addition to pineal gland, human lymphoid
> cells are an important physiological source of melatonin and that
> may be involved in the regulation of the immune system. In this
> work, we examine the effect of melatonin on RAMOS-1 human leukaemic
> cells. Cell growth and viability, DNA fragmentation and JC-1, and
> annexin V expression have been determined. To elucidate the
> mechanism of action of melatonin, Western blot analyses for Bcl-2
> and caspase-3 expression, and cytochrome c release were carried
> out. The results suggest that the apoptotic effect of melatonin is
> associated with cell-cycle arrest, downregulation of Bcl-2,
> mitochondrial membrane depolarization, cytochrome c release and
> activation of caspase-3. The intrinsic (mitochondrial dependent)
> pathway of caspase activation is the 'point of no return'
> commitment to cell death. Taken together, our study indicates that
> melatonin may play a role as potential therapeutic drug in specific
> lymphoproliferative diseases.
> END QUOTE
>
>
> There also was a recent discovery that it is found in large amounts
> in marrow [pers. com. Dr. Jerry Murray]
>
-- Sukie (not a vet)
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