From:
Sukie Crandall
Date: 2005-11-26 00:57:10 UTC
Subject: [ferrethealth] an IBD Question
To: ferrethealth@smartgroups.com
Inflammatory Bowel Disease in ferrets is different from Irritable
Bowel Syndrome in humans, but has anyone tried melatonin with such
ferrets to see if it might reduce symptoms?
START QUOTE
Aliment Pharmacol Ther. 2005 Nov 15;22(10):927-34.
Melatonin improves bowel symptoms in female patients with irritable
bowel syndrome: a double-blind placebo-controlled study.
Lu WZ, Gwee KA, Moochhalla S, Ho KY.
Department of Pharmacology, National University of Singapore, Singapore.
Summary Background : Melatonin is involved in the regulation of
gastrointestinal motility and sensation. Aim : To determine the
potential therapeutic effects of melatonin in irritable bowel
syndrome (IBS). Method : Seventeen female patients satisfying the
Rome II criteria for IBS were randomized to receive either melatonin
3 mg nocte or identically appearing placebo 1 nocte for 8 weeks,
followed by a 4-week washout period and placebo or melatonin in the
reverse order for another 8 weeks. Three validated questionnaires -
the GI symptom, the sleep questionnaires and the Hospital Anxiety and
Depression Scale - were used to assess symptom severity and to
compute the IBS, sleep and anxiety/depression scores, respectively.
Results : Improvements in mean IBS scores were significantly greater
after treatment with melatonin (3.9 +/- 2.6) than with placebo (1.3
+/- 4.0, P = 0.037). Percent response rate, defined as percentage of
subjects achieving mild-to-excellent improvement in IBS symptoms, was
also greater in the melatonin-treated arm (88% vs. 47%, P = 0.04).
The changes in mean sleep, anxiety, and depression scores were
similar with either melatonin or placebo treatment. Conclusions :
Melatonin is a promising therapeutic agent for IBS. Its therapeutic
effect is independent of its effects on sleep, anxiety or depression.
PMID: 16268966 [PubMed - in process
AND QUOTE
-- Sukie (not a vet)
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