From:
Sukie Crandall
Date: 2005-12-01 19:41:58 UTC
Subject: [ferrethealth] the glucose increase might explain a lot about the benefit of high protein diet with most cases of insulinoma
To: ferrethealth@smartgroups.com
One surprise here is that a high protein diet actually can result in
higher sugar levels in the blood than a diet with more starch. This
work is on rats and there are reasons to think this same thing
happens in humans. Taxonomically, primates are closer to rodents
than either group is to members of Carnivora such as ferrets, so how
well this would apply to ferrets is still a knowledge blank to be
filled, though it seems like the sort of thing that may be quite
ancient in which case it often should apply where not lost.
a few excerpts from a much longer article:
> Scientists Uncover Protein's Weight-Loss Secrets
>
> By Alan Mozes
> HealthDay Reporter
>
>
Please, see the publications Cell Metabolism and Healthday for more
info.
...
> The French researchers explain it this way: Protein, the staple of
> such weight-loss regimens, appears to increase glucose production
> in the small intestine -- the rise of which is monitored by the
> liver and then registered by the brain. In turn, the brain sends
> out an "all full" message, cutting back on the drive to eat more...
[Or in the case of ferrets with insulinoma -- improve the blood
glucose level -- IF it applies.]
>
> "The current findings provide an answer to the question of how
> protein-enriched meals decrease hunger and reduce eating, unsolved
> up to now," the study authors, led by Gilles Mithieux of the
> Institut National de la Sante et de la Recherche Medicale in Lyon,
> France, said in a prepared statement.
...
>
> Reporting in the November issue of Cell Metabolism, the French team
> found that by the end of just one week, rats on the protein-rich
> regimen had consumed 15 percent less food than those in the starch-
> diet group.
...
> A more complex explanation for the protein-linked weight loss was
> revealed through blood tests. They showed that two genes
> specifically involved in intestinal glucose production were much
> more active in the protein-diet group compared with the starch-diet
> group.
>
>
>
> Even after food absorption had been completed, the small intestines
> of the protein-diet rats continued to deliver high levels of
> glucose into their portal vein -- a vessel that shuttles blood from
> the digestive system and other organs to the liver.
Of course, there have been some individual ferrets with insulinoma
who simply do not thrive on a high protein diet; cases do vary though
that is not the norm in early or middle stages, but for a number of
end stage insulinoma cases where the ferret's meds are pegged out
adding dietary sugars that are constantly available can at times give
an extra chunk of quality time
Also, remember that there certainly are some ferrets for whom a high
protein diet is contraindicated by existing medical problems,
especially some urinary tract ones.
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