From:
Sukie Crandall
Date: 2005-12-02 21:15:17 UTC
Subject: [ferrethealth] muscle and quality of life post: sarcopenia and aging and a new approach
To: ferrethealth@smartgroups.com, ferret-list@cunyvm.cuny.edu
There is a press release that got forwarded to me by someone I trust
out on some new human geriatric research and new rat research which
might help aging ferrets if it also turns out to apply for them.
Leucine supplementation prevented muscle loss.
The work is from Lydie Combaret, Dominique Dardevet and colleagues at
the Human Nutrition Research Centre of Auvergne, INRA, Clermont-
Ferrand, France.
In humans after 40 we begin to lose 1/2% to 2% of our muscle mass per
year, all else remaining unchanged and the cause -- remember these
are individuals who didn't change in ways that made them couch
potatoes -- is thought to be less effective breakdown of protein into
some of the amino acids. It was already known that adding leucine
restored muscle protein building in the body, but not if leucine
affected the breakdown process itself. It turns out at adding
leucine in rat diets actually improved the process of breaking
digested protein into the amino acids the body uses.
START QUOTE
The team of researchers believe that the age-related problem results
from defective inhibition of ubiquitin-proteasome dependent
proteoloysis, a complex degradative machinery that breaks down
contractile muscle protein, and that leucine supplementation can
fully restore correct function.
"Preventing muscle wasting is a major socio-economic and public
health issue, that we may be able to combat with a leucine-rich
diet," says senior co-author Didier Attaix.
Commenting on the work Michael Rennie from the University of
Nottingham Medical School at Derby says: "This is exciting because it
strengthens the idea of a co-ordinated linkage between the meal-
related stimulation of protein synthesis and the inhibition of
breakdown."
END QUOTE
I will have to search Pubmed.
-- Sukie (not a vet)
Ferret Health List co-moderator
http://www.smartgroups.com/groups/ferrethealth
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