From:
Sukie Crandall
Date: 2006-01-18 04:30:00 UTC
Subject: [ferrethealth] thyroid follicular adenocarcinoma (an abstract)
To: ferrethealth@smartgroups.com
> Vet Clin Pathol. 2005 Dec;34(4):405-8.
> Related Articles, Links
>
> Thyroid follicular adenocarcinoma in a ferret.
>
> Wills TB, Bohn AA, Finch NP, Harris SP, Caplazi P.
>
> Department of Veterinary Clinical Sciences, College of Veterinary
> Medicine, Washington State University, Pullman, WA, USA.
>
> A 5-year-old male castrated ferret was presented to the Washington
> State University College of Veterinary Medicine for evaluation of
> progressive hair loss and a large, rapidly growing ventral neck
> mass. The patient had been diagnosed previously with an insulinoma,
> which was managed medically. Fine-needle aspirates of the neck mass
> were performed. The cytologic results were most consistent with
> epithelial neoplasia, likely a carcinoma; thyroid origin was
> considered likely based on tumor location and cell morphology. The
> tumor grew rapidly, and the owners elected euthanasia 1 week after
> examination. At necropsy, a circumscribed, ovoid mass disrupted the
> right cervical musculature next to the right lobe of the thyroid
> gland. Histopathologic evaluation revealed an infiltrative mass
> consisting of cuboidal cells arranged in solid sheets and irregular
> follicles enclosing colloid. The cells were large, with prominent
> nucleoli, and had a high mitotic rate. The histopathologic
> diagnosis was consistent with thyroid follicular adenocarcinoma.
> Immunochemical findings confirmed thyroglobulin production by
> neoplastic cells, but to a lesser extent than in normal ferret
> thyroid tissue. To our knowledge, this is the first case of thyroid
> follicular adenocarcinoma to be reported in a ferret, with only 1
> other case of thyroid carcinoma, a C-cell carcinoma, described
> previously.
-- Sukie (not a vet)
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