From:
Sukie Crandall
Date: 2006-03-22 18:22:09 UTC
Subject: [ferrethealth] A few abstracts of some new ferret studies which may be of interest
To: FHL <ferrethealth@smartgroups.com>
Sadly, there is still a real problem with many mainstream veterinary
journals and other health resources engaging in the Catch 22 of
refusing to publish more than a handful ferret studies (or sometimes
to keep ferret data) because they say that most of their readers do
not treat ferrets, but without the information in such articles many
vets who want to learn can't reasonably treat ferrets.
Much ferret study data winds up being funded, or being published, or
both for the impacts it has on either human or dog health, rather
than intrinsically for ferrets themselves.
Seeing WHERE these studies appear can not only help find info, but
can help find friendly venues for learning and for publication.
Ex:
Ann Otol Rhinol Laryngol. 2006 Feb;115(2):156-64.
Quantitative and comparative studies of the vocal fold extracellular
matrix. I: Elastic fibers and hyaluronic acid.
Hahn MS, Kobler JB, Starcher BC, Zeitels SM, Langer R.
J Neurosci. 2006 Jan 18;26(3):1057-60.
Restoration of neuronal plasticity by a phosphodiesterase type 1
inhibitor in a model of fetal alcohol exposure.
Medina AE, Krahe TE, Ramoa AS.
> Vet Pathol. 2006 Feb;43(2):97-117.
> Gonadectomy-induced Adrenocortical Neoplasia in the Domestic Ferret
> (Mustela putorius furo) and Laboratory Mouse.
> Bielinska M, Kiiveri S, Parviainen H, Mannisto S, Heikinheimo M,
> Wilson DB.
> Department of Pediatrics, Box 8208, Washington University School of
> Medicine, 660 South Euclid Avenue, St. Louis, MO 63110 (USA).
> wilson_d@wustl.edu.
>
> Sex steroid-producing adrenocortical adenomas and carcinomas occur
> frequently in neutered ferrets, but the molecular events underlying
> tumor development are not well understood. Prepubertal gonadectomy
> elicits similar tumors in certain inbred or genetically engineered
> strains of mice, and these mouse models shed light on tumorigenesis
> in ferrets. In mice and ferrets, the neoplastic adrenocortical
> cells, which functionally resemble gonadal steroidogenic cells,
> arise from progenitors in the subcapsular or juxtamedullary region.
> Tumorigenesis in mice is influenced by the inherent susceptibility
> of adrenal tissue to gonadectomy-induced hormonal changes. The
> chronic elevation in circulating luteinizing hormone that follows
> ovariectomy or orchiectomy is a prerequisite for neoplastic
> transformation. Gonadectomy alters the plasma or local
> concentrations of steroid hormones and other factors that affect
> adrenocortical tumor development, including inhibins, activins, and
> Mullerian inhibiting substance. GATA-4 immunoreactivity is a
> hallmark of neoplastic transformation, and this transcription
> factor might serve to integrate intracellular signals evoked by
> different hormones. Synergistic interactions among GATA-4,
> steroidogenic factor-1, and other transcription factors enhance
> expression of inhibin-alpha and genes critical for ectopic sex
> steroid production, such as cytochrome P450 17alpha-hydroxylase/
> 17,20 lyase and aromatase. Cases of human adrenocortical neoplasia
> have been linked to precocious expression of hormone receptors and
> to mutations that alter the activity of G-proteins or downstream
> effectors. Whether such genetic changes contribute to tissue
> susceptibility to neoplasia in neutered ferrets and mice awaits
> further study.
> J Vet Diagn Invest. 2005 Nov;17(6):594-7.
> Persistent viral shedding during asymptomatic Aleutian mink disease
> parvoviral infection in a ferret.
> Pennick KE, Stevenson MA, Latimer KS, Ritchie BW, Gregory CR.
> Department of Pathology, University of Georgia College of
> Veterinary Medicine, Athens 30602, USA.
>
> A 2-year-old domestic ferret that appeared clinically healthy was
> repeatedly seropositive for Aleutian mink disease parvovirus (ADV)
> over a 2-year observation period. Antibody titers, determined by
> counter-immunoelectrophoresis, ranged from 1024 to 4096. Viral DNA
> also was identified in serum, urine, feces, and blood cell
> fractions by polymerase chain reaction analysis. Ultimately, DNA in
> situ hybridization revealed ADV DNA in histologic sections of
> various tissues and organs. These data indicate that this
> asymptomatic ferret was persistently infected with ADV.
> Vet Clin North Am Exot Anim Pract. 2006 Jan;9(1):69-96.
> Exotic mammal renal disease: diagnosis and treatment.
> Fisher PG.
> Pet Care Veterinary Hospital, 5201-A Virginia Beach Boulevard,
> Virginia Beach, VA 23462, USA. peter.g.fisher@verizon.net
>
> Knowledge of the renal anatomy and clinical pathology associated
> with renal disease can help the practitioner with interpretation of
> imaging procedures and urine, blood, and serum biochemical
> values.This article discusses specimen collection techniques, along
> with species variables in several clinical pathology parameters.
> Diagnostic tools and interpretations are discussed for the more
> common renal maladies affecting exotic mammals. Treatment
> guidelines are offered for general as well as specific exotic
> mammal renal diseases.
> Vet Clin North Am Exot Anim Pract. 2006 Jan;9(1):33-67.
> Exotic mammal renal disease: causes and clinical presentation.
> Fisher PG.
> Pet Care Veterinary Hospital, 5201-A Virginia Beach Boulevard,
> Virginia Beach, VA 23462, USA. peter.g.fisher@verizon.net
>
> Renal disease is not uncommon in exotic mammals, with
> degenerative,infectious (bacterial, viral, parasitic), metabolic,
> nutritional,neoplastic, anatomic, and toxic causes all represented.
> This article discusses the clinical presentation for the various
> renal diseases affecting exotic mammals. Anatomic pathology at the
> gross and microscopic level is reviewed, as is disease
> pathophysiology unique to the species under discussion.
Done for human data, but there is useful ferret data here:
> Infect Immun. 2006 Jan;74(1):769-72.
> A sigma28-regulated nonflagella gene contributes to virulence of
> Campylobacter jejuni 81-176.
> Goon S, Ewing CP, Lorenzo M, Pattarini D, Majam G, Guerry P.
> Enteric Diseases Dept., Naval Medical Research Center, 503 Robert
> Grant Avenue, Silver Spring, MD 20910, USA.
>
> A Campylobacter jejuni 81-176 mutant in Cj0977 was fully motile but
> reduced >3 logs compared to the parent in invasion of intestinal
> epithelial cells in vitro. The mutant was also attenuated in a
> ferret diarrheal disease model. Expression of Cj0977 protein was
> dependent on a minimal flagella structure.
There are others in http://www.ncbi.nlm.nih.gov/entrez/query.fcgi
-- Sukie (not a vet)
Ferret Health List co-moderator
http://www.smartgroups.com/groups/ferrethealth
FHL Archives fan
http://ferrethealth.org/archive/
replacing
http://fhl.sonic-weasel.org
International Ferret Congress advisor
http://www.ferretcongress.org
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