From:
Sukie Crandall
Date: 2006-03-22 18:41:59 UTC
Subject: [ferrethealth] work into how melatonin causes fur growth
To: FHL <ferrethealth@smartgroups.com>
> J Histochem Cytochem. 1996 Apr;44(4):377-87.
>
> Transforming growth factor-alpha immunoreactivity during induced
> hair follicle growth cycles in sheep and ferrets.
>
> Nixon AJ, Broad L, Saywell DP, Pearson AJ.
>
> AgResearch, Ruakura Research Centre, Hamilton, New Zealand.
>
> Transforming growth factor-alpha (TGF-alpha) has been associated
> with cell proliferation of keratinocytes and implicated in hair
> growth. We therefore examined changes in the immunocytochemical
> localization of TGF-alpha and cell proliferation markers in the
> skin of two unrelated species in which hair cycles could be
> induced, to elucidate the role of this growth factor in the control
> of fiber growth. Skin was collected from melatonin-treated ferrets
> (Mustela putorius furo), untreated Romney sheep (Ovis aries), and
> New Zealand Wiltshire sheep in which interruption of wool growth
> had been photoperiodically induced. Immunostaining patterns were
> very similar in ferrets and sheep. TGF-alpha immunoreactivity was
> observed in epithelial tissues of the skin but was not co-localized
> with cell proliferation markers. In anagen follicles, specific
> staining was most intense in the innermost cells of the outer root
> sheath and cortical cells in the keratogenous zone but was absent
> from inner root sheath or dermal papilla. TGF-alpha immunostaining
> diminished during catagen, although faint staining was retained in
> all epithelial cells. In telogen and early proanagen follicles,
> staining remained faint or was restricted to cells on the margin of
> the brush end and follicle neck. Immunoreactivity in the outer root
> sheath was reestablished in late proanagen. Sebaceous glands and
> epidermis were stained intensely throughout the hair cycle. TGF-
> alpha-immunoreactive components of skin extracts, analyzed by
> Western blotting, showed mobility corresponding to approximately 32
> KD, but not to the size of the fully cleaved peptide. These results
> are consistent with an epithelial autocrine or juxtacrine, but not
> a mitogenic, function of TGF-alpha.
-- Sukie (not a vet)
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