Message Number: SG17053 | New FHL Archives SearchFrom: Sukie Crandall
Date: Wed, 05 Apr 2006 11:12:52 -0400
To: FHL <ferrethealth@smartgroups.com>
Subject: [ferrethealth] This is an old abstract on a tracheal topical anesthesia problem
But I have never heard this mentioned before so thought that people
like to know about it:
> Laryngoscope. 1979 Oct;89(10 Pt 1):1697-701.
>
> Adverse effects of lidocaine and methylparaben on tracheal ciliary
> activity.
>
> Mostow SR, Dreisin RB, Manawadu BR, LaForce FM.
>
> The effect of standard concentrations of lidocaine HCl and
> methylparaben (preservative) on the ciliary activity of ferret
> tracheal rings in organ culture was assessed. Pure lidocaine
> concentrations as low as 0.5% caused complete ciliostasis which was
> reversible after removal of the drug. One percent and two percent
> effects were not completely reversible. Pure methylparaben
> concentrations as low as 0.06 mg/ml paralyzed cilia; and, at
> concentrations of 0.5 mg/ml or higher, adverse effects were not
> completely reversible. When lidocaine and methylparaben were
> combined at the same ratio used in commercial preparations, their
> ciliotoxic effects were additive. These data suggest that topical
> respiratory anesthesia may result in prolonged ciliary paralysis.
-- Sukie (not a vet, and not speaking for any of the below in my
private posts)
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