Message Number: SG17182 | New FHL Archives Search
From: sukiec@optonline.net
Date: 2006-04-22 18:11:45 UTC
Subject: [ferrethealth] RE: Sudden behaviour change
To: ferrethealth@smartgroups.com

I am poking around in

http://www.vet.utk.edu/diagnostic/endocrinology/general.shtml#AdrenalFunction

to see if I can find values for you, but not having the best of luck.

In

http://ferrethealth.org/archive/browse.php?msg=YG5743

from 2001

there is this:
> TP was done to see if Bandit has adrenal disease because of hairloss on tail
> and rear feet and lethargy.(update) TP Panel results came back and this is
> what they read:
>
> Estradiol, NMOL/L 140 normal range (30-180)
> 17 OH Progesterone, NMOL/L 0.18 normal range (0-0.8)
> Androstenedione, NMOL/L 16.4 nomal range (0-15)

also from 2001 in

http://ferrethealth.org/archive/browse.php?msg=YG1501

there is

Evaluation of plasma androgen and estrogen concentrations in ferrets
with hyperadrenocorticism.

Rosenthal KL, Peterson ME

Department of Medicine, Animal Medical Center, New York, NY 10021,
USA.

OBJECTIVE: To determine plasma concentrations of steroid hormones in
ferrets with hyperadrenocorticism associated with adrenocortical
neoplasia or nodular hyperplasia of the adrenal gland, the effect of
surgical removal of the affected adrenal gland on concentrations of
these hormones, and whether any hormone concentrations could be used
as a marker for the disease. DESIGN: Prospective case series.
ANIMALS: 32 ferrets with hyperadrenocorticism associated with
adrenocortical neoplasia or nodular hyperplasia of the adrenal gland.
PROCEDURE: A blood sample was obtained from each ferret before
adrenalectomy. In 26 of the 32 ferrets, a second blood sample was
collected 24 to 48 hours after adrenalectomy. Plasma concentrations
of 7 hormones were measured (cortisol, estradiol, testosterone,
progesterone, 17-hydroxyprogesterone, androstenedione, and
dehydroepiandrosterone sulfate). RESULTS: Median plasma
concentrations of 17-hydroxyprogesterone, androstenedione, and
dehydroepiandrosterone sulfate were significantly higher in ferrets
with adrenal gland disease, compared with concentrations in
clinically normal ferrets. After adrenalectomy, median concentrations
of estradiol, 17-hydroxyprogesterone, and androstenedione decreased
significantly. Of 23 ferrets in which concentrations of estradiol, 17-
hydroxyprogesterone, and androstenedione all were measured, 22 (96%)
had high concentrations of at least 1 of these 3 hormones, but only 5
(22%) ferrets had high concentrations of all 3 hormones. CLINICAL
IMPLICATIONS: The condition that develops in ferrets with adrenal
gland disease apparently is caused by excessive secretion of 1 or
more steroids other than cortisol. Because concentration of a
particular hormone was not high in all ferrets, we recommend
determining plasma concentrations of several sex steroids, including
androstenedione, 17-hydroxyprogesterone, and estradiol.

In _Ferrets, Rabbits and Rodents, Clinical Medicine and Surgery, 2nd ed._ on page 85

Androstenedione (nmol/L)
Adrenal disease Neutered Mean (Hereafter ADM in this post) 67 (n=25)
Mean Normal Neutered (Hereafter MN in this post) 6.6
Reference Range Normal Neutered (Hereafter RRN in this post) <0.1-15
Mean Whole Females (hereafter MW in this post) 58.3
Reference Range Whole Females (hereafter RRW in this post) 20-96

Dehydroepiandrosterone sulfate (umol/L
ADM 0.03 (n=27)
MN 0.01
No figures for the others

Estradiol (pmol/L)
ADM 167 (n=28)
MN 106
RRN 30-108
MW 165.5
RRW 122-210

17-HYdrooxyprogesterone (nmol/L)
ADM 3.2 (n=20)
MN 0.4
RRN <0.1-0.8
MW 7.7
RRW 2.3-13.1

-- Sukie (not a vet, and not speaking for any of the below in my private posts)
Recommended health resources to help ferrets and the people who love them:
Ferret Health List
http://www.smartgroups.com/groups/ferrethealth
FHL Archives
http://ferrethealth.org/archive/
AFIP Ferret Pathology
http://www.afip.org/ferrets/index.html
Miamiferrets
http://www.miamiferret.org/fhc/
International Ferret Congress Critical References
http://www.ferretcongress.org





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