From:
sukiec@optonline.net
Date: 2006-05-29 15:34:11 UTC
Subject: [ferrethealth] exercise and reductions in death from malignancies
To: ferrethealth@smartgroups.com
In PubMed there are over 800 articles found when that topic is searched upon.
A recent study *might* fill in a very important blank which had existed for knowing how getting enough exercise reduces malignancy rates (looked at in other studies), or mortality during a malignancy (looked at in this study), or both. Studies already show that exercise reduces a wide range of malignancy rates and improves survival.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16299029&query_hl=2&itool=pubmed_docsum
For the physically active, increasing IGFBP-3 by 26.2 nmol/l was associated with a 48% reduction in colorectal cancer specific deaths
>From an Reuters article by Martha Kerr:
>insulin-like binding protein-3 (IGFBP-3), inhibits another protein called insulin-like growth factor-1 (IGF-1), thereby >blocking IGF-1's proliferative effect on cell growth...
Haydon told Reuters Health that that "physical activity can increase IGFBP-3 levels, which, in turn, reduces the amount of free IGF-1." IGF-1 has been shown to stimulate cell growth, inhibit cell death, and promote angiogenesis -- the formation of new blood vessels, which tumors need to grow...
"Other studies that have looked at this have shown a dose-effect, meaning the more exercise the lower the risk...
While this was a human study there is a very reasonable chance of this mechanism generalizing to other mammals and other types of malignancies.
Exercise is a very important part of health.
Sent from website
5/29/06. 11:32 a.m. EST U.S.
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