From:
sukiec@optonline.net
Date: 2006-06-03 15:33:44 UTC
Subject: [ferrethealth] renal failure abstract
To: ferrethealth@smartgroups.com
START QUOTE
Exp Biol Med (Maywood). 2006 Jun;231(6):997-1000.
Links
Primary structure of cat preproendothelin-2 and cat renal mRNA expression o=
f preproendothelin-1 and preproendothelin-2 in naturally occurring renal fa=
ilure.
Uchide T, Saida K.
Department of Toxicology, School of Veterinary Medicine and Animal Sciences=
, Kitasato University, 35-1 Higashi 23-bancho, Towada, Aomori 034-8628, Jap=
an. uchide@vmas.kitasato-u.ac.jp.
Endothelin (ET)-1 is involved in the pathophysiology of various renal disor=
ders, promoting renal cellular proliferation and extracellular matrix prote=
in accumulation, and, thus, diminishing fundamental renal function, includi=
ng filtration. To determine whether ET-1 and ET-2 play a role in feline chr=
onic renal failure, we analyzed the messenger RNA (mRNA) expression of the =
prepro-ET (PPET )-1 and PPET-2 genes in affected cat kidney after molecular=
cloning of full-length PPET-2 complementary DNA (cDNA). Conceptual analysi=
s of the primary structure of cat PPET-2 based on the cloned sequence demon=
strated that the putative regions corresponding to a mature peptide and pep=
tidase processing sites are present in cat PPET-2. Homology analysis showed=
that the similarity of the cat PPET-2 amino acid sequence with those from =
human, mouse, rat, rabbit, dog, ferret, cow, and horse was 73.0%, 68.6%, 69=
.1%, 76.4%, 81.2%, 83.1%, 76.3%, and 79.2%, respectively. Analysis of PPET-=
1 and PPET-2 mRNA in cat by reverse transcription polymerase chain reaction=
showed upregulated expression of both genes in kidneys affected by renal f=
ailure.
PMID: 16741037 [PubMed - in process]
END QUOTE
-- Sukie (not a vet, and not speaking for any of the below in my private po=
sts)
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