From:
sukiec@optonline.net
Date: 2006-06-27 16:29:45 UTC
Subject: [ferrethealth] RE: Is Leishmaniasis a problem for ferrets??
To: ferrethealth@smartgroups.com
An abstract from 1989 (but no later ones found with these search terms):
START QUOTE
Lab Anim Sci. 1989 Jan;39(1):47-50. =
A comparison of experimental visceral leishmaniasis in the opossum, armadil=
lo and ferret.
White MR, Chapman WL Jr, Hanson WL.
Department of Pathology, College of Veterinary Medicine, University of Geor=
gia, Athens 30602.
Visceral leishmaniasis is a severe, chronic protozoal disease of humans and=
animals. Although chemotherapeutic agents are available for the treatment =
of this disease, problems such as drug toxicity, drug ineffectiveness and d=
rug resistance of the parasite are responsible for treatment failures. To d=
etermine whether a drug is a potential antileishmanial agent, screening tes=
ts are performed using in vitro and in vivo models. Subsequently, a study u=
sing an appropriate animal model is performed to clearly determine the effi=
cacy of a drug against Leishmania. Due to current public concerns regarding=
the use of companion animals in addition to the high costs of obtaining an=
d maintaining these animals for research use, conventional animal models us=
ed in these chemotherapy studies, notably the dog and monkey, are becoming =
less acceptable. Therefore, new, less expensive and more accessible animal =
models are needed for the study of antileishmanial compounds. In this study=
, the armadillo, ferret and opossum were evaluated as possible new animal m=
odels for visceral leishmaniasis. The marked body weight loss, hepatomegaly=
, splenomegaly, large amastigote densities and the microscopic lesions obse=
rved in the infected opossums indicated that the opossum was more susceptib=
le to visceral leishmaniasis than the armadillo or ferret.
PMID: 2918684 [PubMed - indexed for MEDLINE]
END QUOTE
Three different search word combinations picked up the one same result.
This may also interest you:
START QUOTE
Med Hypotheses. 2006 Jun 22; [Epub ahead of print] =
Are New World leishmaniases becoming anthroponoses?
Rotureau B.
Laboratoire Hospitalo-universitaire de Parasitologie et Mycologie Medicale,=
Equipe EA 3593, Unite de Formation et de Recherche en Medecine de l'Univer=
site des Antilles et de la Guyane, Campus Saint-Denis, BP 718, 97336 Cayenn=
e, French Guiana.
In the New World, leishmaniases are originally wild exoanthropic zoonoses d=
eveloping in sylvatic ecotopes. For a long time, Leishmania parasites have =
shown a remarkable plasticity to face modifications in their environment. N=
ow, both geographical extension and numerical increase of leishmaniasis cas=
es in the New World are giving cause for concern. These circumstances might=
have been provoked by the simple invasion of zoonotic foci by humans. Howe=
ver, dramatic evolutionary mechanisms are also at work in the New World: (i=
) the reduction of biodiversity associated with anthropogenic environmental=
changes (deforestation and urbanization); and (ii) the subsequent adaptati=
ons and interactions of new vectors and reservoir hosts at the interface wi=
th humans. This paper considers that these processes could result in new pa=
thogenic complexes tending to synanthropic zoonoses, if not anthroponoses. =
Increasing man-made risk factors could thus possibly make leishmaniases a g=
rowing public health concern in the New World.
PMID: 16797861 [PubMed - as supplied by publisher]
END QUOTE
Leishmania forms are very wide-spread in the world.
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