Message Number: SG17833 | New FHL Archives Search
Date: 2006-07-09 16:31:16 UTC
Subject: [ferrethealth] Liver damage and low estradiol

Can any vet or others comment on low estradiol <10.0 pmol/L being an early
indicator of liver malfunction.
see containing my question
<Estradiol pmol/L 107 +/- 38 180 <10.0 Very low, can this be right?>

10 weeks later this ferret was found to have a massive liver tumour

I ask this question because of the relationship between hepatocytes and estradiol
see extract below
Estradiol treatment modified the metabolic responses of fasted rat hepatocytes to
exogenous glucose with respect to
glucose utilization and cytosolic NADPH-generating enzymes. The estrogen
abolished the glucose-stimulated gluconeogenic capacity displayed by control rat
cells while promoting a net uptake of exogenous glucose and enhancing the
glucose-6-phosphate dehydrogenase activity. Estradiol also caused an increase in
the activity of the isocitrate dehydrogenase that may be related to the enhanced
needs of NADPH by hepatocytes for steroid hormone catabolism

Estradiol protects hepatocytes from oxidative damage by means of its antioxidant

If the ferrets small remaining good liver tissue was <being overworked> could this
have utilised more estradiol resulting in low reading obtained in hormone panel.

This may be a stupid question, if it is, tell me.

In memory of Sue

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