From:
sukiec@optonline.net
Date: 2006-09-14 18:41:26 UTC
Subject: [ferrethealth] reducing arrhythmia with fish oil; a diet study on ferrets in relation to liver disease
To: ferrethealth@smartgroups.com
Having had ferrets with heart rhythm problems I figured that this might be =
useful:
It looks like fish oil which is high in Omega 3 Fatty Acids is good for suc=
h problems.
Here is a meta-analysis of animal studies:
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=3Dpubmed&cmd=3DRetrieve&d=
opt=3DAbstractPlus&list_uids=3D16311086&query_hl=3D9&itool=3Dpubmed_docsum>=
Metabolism. 2005 Dec;54(12):1557-65.
Links
A systematic review and meta-analysis of the impact of omega-3 fatty acids =
on selected arrhythmia outcomes in animal models.
Matthan NR, Jordan H, Chung M, Lichtenstein AH, Lathrop DA, Lau J.
Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Resear=
ch Center on Aging, Tufts University, Boston, MA 02111, USA. nirupa.matthan=
@tufts.edu
Epidemiological studies and clinical trials report the beneficial effects o=
f fish or fish oil consumption on cardiovascular disease outcomes including=
sudden death. We performed a systematic review of the literature on contro=
lled animal studies that assessed the effects of omega-3 fatty acids on sel=
ected arrhythmia outcomes. On the basis of predetermined criteria, 27 relev=
ant animal studies were identified; 23 of these were feeding studies, and 4=
were infusion studies. Across species, fish oil, eicosapentaenoic acid, an=
d/or docosahexaenoic acid appear to have beneficial effects on ventricular =
tachycardia (VT) and fibrillation (VF) in ischemia- but not reperfusion-ind=
uced arrhythmia models; no effect on the incidence of death and infarct siz=
e; and inconsistent results with regard to arrhythmia score, VF threshold, =
ventricular premature beats or length of time in normal sinus rhythm, compa=
red to omega-6, monounsaturated, or saturated fatty acids, and no treatment=
controls. In a meta-analysis of 13 studies using rat models, fish oil but =
not alpha-linolenic acid supplementation showed a significant protective ef=
fect for ischemia- and reperfusion-induced arrhythmias by reducing the inci=
dence of VT and VF. It is not known whether omega-3 fatty-acid supplementat=
ion has antiarrhythmic effects in other disease settings not related to isc=
hemia.
PMID: 16311086 [PubMed - indexed for MEDLINE]
END QUOTE
The most recent human work which got me looking this up is not yet on PubMe=
d.
If you look up
(ferret or ferrets or mustela) and arrhythmia
In Pubmed there are 38 articles on that topic category but I did not find a=
ny specifically in relation to Omega 3
In doing that I DID find a diet study on ferrets in relation to liver disea=
se from 10 years ago from which I will include the abstract of since that m=
ight interest some:
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=3Dpubmed&cmd=3DRetrieve&d=
opt=3DAbstractPlus&list_uids=3D8814340&query_hl=3D16&itool=3Dpubmed_docsum>=
The diets tested were:
A, meat and biscuit; =
B, all meat; =
C, meat and fish; =
D, high fibre) =
to ascertain the cause of spontaneous development of fatty liver. =
High hepatic triglyceride contents resulted on diets B =3D C > D; whereas f=
errets on diet A (control) showed no accumulation of lipid in liver.
It would be interesting with what is currently known of liver behavior in f=
errets to find if what was seen was the result of true fatty liver disease =
in relation to
Controversy and Confusion in Interpretation of Ferret Clinical Pathology:
http://www.afip.org/ferrets/Clin_Path/ClinPath.html
and
When answers create more questions =96 deciphering ferret GI pathology repo=
rts
http://www.afip.org/ferrets/PDF/Ferret_GI_path_reports.pdf
Here is the abstract:
START QUOTE
Toxicology. 1996 Aug 16;112(2):105-16.
Links
Spontaneous development of fatty liver in ferrets in a toxicology study.
Shavila J, King LJ, Parke DV.
School of Biological Sciences, University of Surrey, Guildford, UK.
Ferrets were maintained for 12 months on different diets (A, meat and biscu=
it; B, all meat; C, meat and fish; D, high fibre) to ascertain the cause of=
spontaneous development of fatty liver. High hepatic triglyceride contents=
resulted on diets B =3D C > D; whereas ferrets on diet A (control) showed =
no accumulation of lipid in liver. Serum triglyceride and total cholesterol=
were unchanged by diet. These ferrets (F0 generation) were mated with ferr=
ets on the same diet and the offspring (F1 generation), maintained on the s=
ame diets as the parents, were killed at 12 months and the livers studied s=
imilarly. Histology showed that hepatic lipid accumulation in the F1 genera=
tion was identical with that in the same dietary groups of the F0 generatio=
n; liver glutathione (GSH) reductase and thiobarbituric acid-reacting subst=
ances (an index of lipid peroxidation) were increased in ferrets maintained=
on diets B, C and D, liver GSH concentration and GSH peroxidase activities=
were unchanged. Other ferrets fed a high-fat diet (diet A plus 20% w/w bee=
f suet) for 18 days exhibited hepatic lipid accumulation and decreased hepa=
tic cyanide-insensitive palmitoyl CoA oxidation (-30%), but hepatic lauric =
acid hydroxylation and carnitine acyl transferase activities were unchanged=
. These data indicate that ferrets on high-fat diets show no increased rate=
s of liver fatty acid oxidation, as seen in rats, but instead accumulate tr=
iglyceride in the liver with some degree of lipid peroxidation.
PMID: 8814340 [PubMed - indexed for MEDLINE]
END QUOTE
-- Sukie (not a vet, and not speaking for any of the below in my private po=
sts)
Recommended health resources to help ferrets and the people who love them:
Ferret Health List
http://www.smartgroups.com/groups/ferrethealth
FHL Archives
http://ferrethealth.org/archive/
AFIP Ferret Pathology
http://www.afip.org/ferrets/index.html
Miamiferrets
http://www.miamiferret.org/fhc/
International Ferret Congress Critical References
http://www.ferretcongress.org
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