From:
sukiec@optonline.net
Date: 2006-09-17 23:02:20 UTC
Subject: [ferrethealth] CDV study
To: ferrethealth@smartgroups.com
BEGIN QUOTE
J Virol. 2006 Oct;80(19):9361-70.
Canine Distemper Virus Uses both the Anterograde and the Hematogenous Pathw=
ay for Neuroinvasion.
Rudd PA, =
Cattaneo R, =
von Messling V.
INRS-Institut Armand-Frappier, University of Quebec, 531, Boul. des Prairie=
s, Laval, Quebec H7V 1B7, Canada. =
Canine distemper virus (CDV), a member of the Morbillivirus genus that also=
includes measles virus, frequently causes neurologic complications, but th=
e routes and timing of CDV invasion of the central nervous system (CNS) are=
poorly understood. To characterize these events, we cloned and sequenced t=
he genome of a neurovirulent CDV (strain A75/17) and produced an infectious=
cDNA that expresses the green fluorescent protein. This virus fully retain=
ed its virulence in ferrets: the course and signs of disease were equivalen=
t to those of the parental isolate. We observed CNS invasion through two di=
stinct pathways: anterogradely via the olfactory nerve and hematogenously t=
hrough the choroid plexus and cerebral blood vessels. CNS invasion only occ=
urred after massive infection of the lymphatic system and spread to the epi=
thelial cells throughout the body. While at early time points, mostly immun=
e and endothelial cells were infected, the virus later spread to glial cell=
s and neurons. Together, the results suggest similarities in the timing, ta=
rget cells, and CNS invasion routes of CDV, members of the Morbillivirus ge=
nus, and even other neurovirulent paramyxoviruses like Nipah and mumps viru=
ses.
PMID: 16973542 [PubMed - in process]
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