Message Number: SG18372 | New FHL Archives Search
Date: 2006-10-01 22:06:31 UTC
Subject: [ferrethealth] canine distemper variations

Recently, I contacted a researcher, Dr. Steve Kleiboeker to learn more in r=
esponse to a member's question about the abstract quoted at the bottom of t=
he page. I have had his reply for a week and must apologize for this week =
being such that I could not carry this information to the FHL.

Not having his permission to quote him I will paraphrase and use short quot=
es since I don't know if part of what he said may be sensitive.

He began his letter pointing out that there are new strains of Canine Diste=
mper circulating and that vaccine protection studies are lacking for these =
in any species, meaning that current vaccines may or may not protect agains=
t them.

Then he pointed out that there were questions about how vaccination was pra=
cticed at the facilities where the studied cases originated. He emphasized=
that improperly stored or improperly administered canine distemper vaccina=
tions tend to not work, but that elsewhere these strains do not seem to be =
showing up in dogs over the year between, even in the same region, so the s=
trains may be very rare or current vaccines when stored and administered pr=
operly may work just fine in dogs (perhaps in other species...).

The abstract:


J Clin Microbiol. 2005 October; 43(10): 5009-5017.
doi: 10.1128/JCM.43.10.5009-5017.2005.
Copyright =A9 2005, American Society for Microbiology

Phylogenetic Characterization of Canine Distemper Viruses Detected
in Naturally Infected Dogs in North America
Ingrid D. R. Pardo, Gayle C. Johnson, and Steven B. Kleiboeker*

Veterinary Medical Diagnostic Laboratory and the Department of
Veterinary Pathobiology, University of Missouri, College of
Veterinary Medicine, Columbia, Missouri 65211

*Corresponding author. Mailing address: Department of Veterinary
Pathobiology and Veterinary Medical Diagnostic Laboratory,
University of Missouri, 1600 E. Rollins, Columbia, MO 65211. =

Received April 5, 2005; Revised May 27, 2005; Accepted July 19, 2005.


In 2004, six puppies and one adult dog from a total of four
premises were subjected to necropsy evaluation. For five of the
seven dogs, disease caused by canine distemper virus (CDV)
infection was suspected based on clinical signs. In all of the
dogs, a diagnosis of CDV infection was established by the presence
of compatible gross and histologic lesions, immunohistochemical
labeling for CDV antigen, and detection of CDV RNA by reverse
transcription-PCR. To further characterize the CDV strains detected
in the four cases, complete gene sequences were determined for the
hemagglutinin (H) and fusion (F) protein genes, while partial gene
sequencing was performed for the phosphoprotein gene. A total of
4,508 bases were sequenced for the CDV strains detected from each
of the four cases. Two cases were found to have identical sequences
except for 2 bases in the intergenic region of the F and H genes.
Phylogenetic analysis strongly suggested an evolutionary
relationship between sequences detected in these two cases and
those of phocine distemper virus 2 and two other strains of CDV not
previously detected in the continental United States. Clear
phylogenetic relationships were not established for viruses
detected in the two additional cases; however, one strain showed
similarity to CDV strains detected in a panda from China.
Importantly, the three CDV strains detected were demonstrated to be
genetically distinct from known vaccine strains and strains
previously reported in the continental United States.

and locating the full article here:


-- Sukie Crandall
(not a vet)
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