From:
sukiec@optonline.net
Date: 2006-10-22 01:48:28 UTC
Subject: [ferrethealth] RE: possible campylobacter
To: ferrethealth@smartgroups.com
There MIGHT be another reason to not give an acid blockers when treating an=
upper GI infection which may be antibiotic resistant. =
In the latest issue of Science News there will be an article on such medica=
tion use (n mice) backfiring with hard to extricate colonic infections.
I'll put some short quotes to give you an idea and those who want to see th=
e full article and are not subscribers can ask their area libraries to find=
a copy.
START ATTRIBUTIONS AND QUOTED SEGMENTS
Week of Oct. 21, 2006; Vol. 170, No. 17 , p. 269, Science News
Do acid blockers let microbes reach the colon?
Nathan Seppa
Suppressing stomach acid while taking antibiotics may allow antibiotic-resi=
stant bacteria to colonize the intestines, a study shows...
Researchers had previously linked stomach-acid suppression to pneumonia (SN=
: 10/30/04, p. 277...
researchers gave mice two kinds of live, resistant bacteria via a feeding =
tube over 3 days. The animals then received an acid-suppressing drug, the a=
ntibiotic clindamycin, or both. The acid blocker was a proton-pump inhibito=
r called pantoprazole...
The bacteria colonized the intestines of the mice receiving both the acid b=
locker and the antibiotic more than three times as often as they did the in=
testines of mice receiving the antibiotic alone, says Curtis J. Donskey, an=
infectious-disease physician at the Louis Stokes Cleveland Veterans Affair=
s Medical Center in Ohio. He presented the findings at the 46th Interscienc=
e Conference on Antimicrobial Agents and Chemotherapy in San Francisco last=
month...
Both factors=97acid suppression and an antibiotic=97were needed to make the=
intestines a welcoming home to the resistant microbes... =
the antibiotic suppressed natural, protective microbes, while the invading=
drug-resistant bacteria thrived, he says.
END QUOTED SEGMENTS
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