From:
sukiec@optonline.net
Date: 2006-10-26 14:49:23 UTC
Subject: [ferrethealth] new abstract (modulation of esophageal and gastric neural pathways)
To: ferrethealth@smartgroups.com
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=3Dpubmed&cmd=3DRetrieve&d=
opt=3DAbstractPlus&list_uids=3D17053158&query_hl=3D1&itool=3Dpubmed_docsum>=
BEGIN QUOTE
Am J Physiol Gastrointest Liver Physiol. 2006 Oct 19; [Epub ahead of print]=
Peripheral versus central modulation of gastric vagal pathways by metabotro=
pic glutamate receptor 5.
Young RL, Page A, O'donnell TA, Cooper NJ, Blackshaw LA.
Department of Gastroenterology, Hepatology & General Medicine, Royal Adelai=
de Hospital, Nerve-Gut Research Laboratory, Hanson Institute, Adelaide, Sou=
th Australia, Australia; Discipline of Medicine, University of Adelaide, Ad=
elaide, South Australia, Australia.
Metabotropic glutamate receptors (mGluR) are classified into Group I, II an=
d III mGluR. Group I (mGluR1, mGluR5) are excitatory whilst Group II and II=
I are inhibitory. mGluR5 antagonism potently reduces triggering of transien=
t lower esophageal sphincter relaxations (TLESR) and gastroesophageal reflu=
x. TLESR are mediated via a vagal pathway and initiated by distension of th=
e proximal stomach. Here we determined the site of action of mGluR5 in gast=
ric vagal pathways by investigating peripheral responses of ferret gastroes=
ophageal vagal afferents to graded mechanical stimuli in vitro and central =
responses of nucleus tractus solitarius (NTS) neurons with gastric input in=
vivo in the presence or absence of the mGluR5 antagonist MPEP. mGluR5 were=
also identified immunohistochemically in the nodose ganglia and NTS after =
extrinsic vagal inputs had been traced from the proximal stomach. Gastroeso=
phageal vagal afferents were classified as mucosal, tension, or tension muc=
osal (TM) receptors. MPEP (1-10 microM) inhibited responses to circumferent=
ial tension of tension and TM receptors. Responses to mucosal stroking of m=
ucosal and TM receptors were unaffected. MPEP (0.001-10 nmole, icv) had no =
major effect on the majority of NTS neurons excited by gastric distension o=
r on NTS neurons inhibited by distension. mGluR5 were abundant in gastric v=
agal afferent neurons and sparse in fibers within NTS vagal subnuclei. We c=
onclude that mGluR5 play a prominent role at gastroesophageal vagal afferen=
t endings but a minor role in central gastric vagal pathways. Peripheral mG=
luR5 may prove a suitable target for reducing mechanosensory input from the=
periphery, for therapeutic benefit. Key words: metabotropic glutamate rece=
ptor 5, vagal afferent mechanosensitivity, nucleus tractus solitarius, immu=
nohistochemistry, retrograde tracing.
PMID: 17053158 [PubMed - as supplied by publisher]
END QUOTE
-- Sukie (not a vet, and not speaking for any of the below in my private po=
sts)
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