Message Number: YPG42 | New FHL Archives Search
From: "Sukie Crandall"
Date: Tue, 07 Nov 2006 21:59:29 -0000
Subject: [ferrethealth] Re: posted pics of before-after melatonin implant
Remember, though, that there are TWO mechanisms through which melatonin can cause
the regrowth of fur and one of those does nothing to help with the adrenal growth itself,
so the adrenal growth might be getting some help but it might not when the only sign is a
regrowth of fur.
J Histochem Cytochem. 1996 Apr;44(4):377-87. Links
Transforming growth factor-alpha immunoreactivity during induced hair follicle growth
cycles in sheep and ferrets.
AgResearch, Ruakura Research Centre, Hamilton, New Zealand.
Transforming growth factor-alpha (TGF-alpha) has been associated with cell proliferation
of keratinocytes and implicated in hair growth. We therefore examined changes in the
immunocytochemical localization of TGF-alpha and cell proliferation markers in the skin
of two unrelated species in which hair cycles could be induced, to elucidate the role of this
growth factor in the control of fiber growth. Skin was collected from melatonin-treated
ferrets (Mustela putorius furo), untreated Romney sheep (Ovis aries), and New Zealand
Wiltshire sheep in which interruption of wool growth had been photoperiodically induced.
Immunostaining patterns were very similar in ferrets and sheep. TGF-alpha
immunoreactivity was observed in epithelial tissues of the skin but was not co-localized
with cell proliferation markers. In anagen follicles, specific staining was most intense in
the innermost cells of the outer root sheath and cortical cells in the keratogenous zone
but was absent from inner root sheath or dermal papilla. TGF-alpha immunostaining
diminished during catagen, although faint staining was retained in all epithelial cells. In
telogen and early proanagen follicles, staining remained faint or was restricted to cells on
the margin of the brush end and follicle neck. Immunoreactivity in the outer root sheath
was reestablished in late proanagen. Sebaceous glands and epidermis were stained
intensely throughout the hair cycle. TGF-alpha-immunoreactive components of skin
extracts, analyzed by Western blotting, showed mobility corresponding to approximately
32 KD, but not to the size of the fully cleaved peptide. These results are consistent with an
epithelial autocrine or juxtacrine, but not a mitogenic, function of TGF-alpha.
PMID: 8601697 [PubMed - indexed for MEDLINE]
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