From:
"Sukie Crandall"
Date: 2006-12-14 00:35:59 UTC
Subject: [ferrethealth] Re: desperate for help!!
To: ferrethealth@yahoogroups.com
BTW, if difficult sores are developing and it gets to the point where the v=
ets choose to
experiment there is a new human health study (on rats) in wound healing:
BEGIN QUOTE
Public release date: 10-Dec-2006
Contact: John Fleischman
jfleischman@ascb.org
513-929-4635
American Society for Cell Biology
>From managing sugar to managing healing
Why applying insulin to wounds significantly enhances healing
Insulin is a hormone known primarily for regulating sugar levels in the blo=
od, yet
researchers at the University of California, Riverside, recently found that=
applying insulin
directly to skin wounds significantly enhanced the healing process.
Skin wounds in rats treated topically with insulin healed faster"surface ce=
lls in the
epidermis covered the wound more quickly and cells in the dermis, the deepe=
r part of the
skin, were faster in rebuilding blood vessels.
In follow-up studies of human skin cells in culture, Manuela Martins-Green =
and colleagues
explored the molecular impact of topical insulin on keratinocytes, the cell=
s that regenerate
the epidermis after wounding, and on microvascular endothelial cells, the c=
ells that restore
blood flow.
Using various cell and molecular techniques, the researchers discovered tha=
t insulin
stimulates human keratinocytes in culture to proliferate and migrate. In cu=
ltured human
microvascular endothelial cells, the insulin stimulates only migration into=
the wound
tissue. The insulin works by switching on cellular signaling proteins calle=
d kinases
(specifically Src, PI3K, and Akt) and a protein (SREBP) that binds elements=
in DNA that
regulate the production of cholesterol and its relatives.
Chronic or nonhealing wounds take an immense toll on American health and on=
health
care systems. It particularly affects millions of patients with impaired mo=
bility, as well as
those with diabetes. Because diabetes is a disease caused by impaired produ=
ction or
utilization of insulin, this work may help explain the connection between d=
iabetes and
poor healing.
Says Martins-Green, "This work is important because when we know which cell=
s respond
to insulin and which molecules are involved, we may be able to develop ways=
in which we
can make insulin work even better or find ways in which more affordable mol=
ecules that
mimic these functions of insulin can be developed to treat people who suffe=
r from poor
healing."
###
News from
The American Society for Cell Biology
46th Annual Meeting
San Diego, CA
December 9=9613, 2006
Author presents
Sunday, December 10
1:30 pm=963:00 pm
Session 110
Growth Factors and Receptors
Presentation 74
Poster Board B14
Halls C-G
Insulin and Healing: Cell and Molecular Mechanisms Leading to Acceleration =
of Wound
Healing
Y. Liu*, M. Yao#, M. Martins-Green
Cell Biology & Neuroscience
University of California, Riverside
Riverside, CA
*On leave from Burn Department, Ruijin Hospital, Shanghai JiaoTong Universi=
ty Medical
School, Shanghai, P.R. China, 200025
#Now at Wellman Center for Photomedicine, Massachusetts General Hospital, H=
arvard
Medical School, Boston, MA 02114
END QUOTE
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