From:
"Sukie Crandall"
Date: 2007-06-02 17:36:32 UTC
Subject: [ferrethealth] Re: dosing help
To: ferrethealth@yahoogroups.com
Phenoxybenzamine is also called Dibenzyline, but that is also not in the archives
Searching brings up a pdf of a dissertation but the font is small and when
enlarged it becomes to fuzzy, so one way or the other I can't see if it has any help for you:
http://dissertations.ub.rug.nl/FILES/faculties/science/1991/h.h.g.berendsen/thesis.pdf
If you write to me privately with info on who wrote the article and where the person is
located I may be able to find that expert's contact info for your vet but i can't promise
success, obviously. Please, share the data on dosing and results when you have them!
Ferrets are not mentioned in
http://www.veterinarypartner.com/Content.plx?P=A&A=2153
nor in
http://www.veterinarypartner.com/Content.plx?P=A&S=0&C=0&A=1322
(ferret emergencies)
http://www.veterinarypartner.com/Content.plx?P=A&S=0&C=0&A=478
(ferret prostates, but he piece is old enough to mention Lysodren which is pretty
completely abandoned. it does mention Lupron and Flutamide.)
and the med is not in
http://www.veterinarypartner.com/Content.plx?P=A&S=0&C=0&A=669
nor can I find the med in any other article.
Your vet may have encountered it in a discussion on VIN in which case the author
may be able to help.
Okay, there are three old articles coming up in PubMed so let me see if I can find
if any are applicable.
http://www.ncbi.nlm.nih.gov/sites/entrez?
Db=pubmed&Cmd=ShowDetailView&TermToSearch=8267674
did not have that med looked at in that species
http://www.ncbi.nlm.nih.gov/sites/entrez?
Db=pubmed&Cmd=ShowDetailView&TermToSearch=3025931
has the amount used in a study on trachea, not bladders, but your vet might want it:
BEGIN QUOTE OF ABSTRACT
Prostaglandins. 1986 Aug;32(2):189-200.
Pharmacology of peptide leukotrienes on ferret isolated airway smooth muscle.
Snyder DW, Krell RD.
The contractile activities of peptide leukotrienes (LT) on isolated spiral strips of ferret
trachea were characterized pharmacologically. LTC4 and LTD4 contracted ferret tracheal
strips in a concentration-related manner and were 3- to 8-fold more potent than
carbachol.
In contrast, high concentrations of LTE4 evoked either weak contractions or none at all,
whereas LTC4 and D4 were partial agonists compared to carbachol. In tissues which were
unresponsive to LTE4, this compound antagonized contractile responses to LTC4 and D4
in an apparently competitive manner: Carbachol-induced contractions were not altered by
LTE4. The cyclooxygenase inhibitor, indomethacin (5 microM), LT antagonist, FPL55712
(10 microM), atropine (1 microM), phenoxybenzamine (10 microM), and LTB4 (10 microM)
failed to alter LTC4 and D4 concentration-response curves. The results indicate that ferret
trachea is sensitive to the contractile activity of LTC4 and LTD4 but not LTE4. The LT-
induced
contractions appear to be mediated by a direct action of the LT rather than indirectly
through
release of secondary mediators such as thromboxane, prostaglandin, or acetylcholine. LT
receptors in ferret trachea are insensitive to FPL55712 but are antagonized by LTE4.
PMID: 3025931 [PubMed - indexed for MEDLINE]
END QUOTE
There is also
http://www.ncbi.nlm.nih.gov/sites/entrez?
Db=pubmed&Cmd=ShowDetailView&TermToSearch=2577682
Vet Contact doesn't bring up anything.
http://ajpcell.physiology.org/cgi/content/full/280/2/C254?ck=nck
just looks at the ferret aorta and seems to be a different compound, but check me
http://www.evergreenvetclinic.com/petcare.html
comes up for those search terms but I not only can't find them together but I can't find
one of the search terms
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/fhc/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
--- In ferrethealth@yahoogroups.com, "Sheryl" <miwok34@...> wrote:
>
> My vet wants to prescribe Phenoxybenzamine for Mojave except she can't
> find the dosing for ferrets and I couldn't find anything about it in
> the archives. Does anyone know the dosage for ferrets or can give us
> some info on how to get the information?
>
> She said that she saw on VIN that it can be used on ferrets but did
> not see anything about dosage. She is going to do research on it this
> weekend and I told her that I would post a message to see if you guys
> can help us out.
>
> If I remember correctly (she called me while I was at work yesterday)
> it is a muscle relaxant that doesn't affect the whole body. She said
> something like it works on the bladder.
>
> Thank you,
>
> Sheryl
>
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