From:
"Sukie Crandall"
Date: 2007-06-25 14:28:51 UTC
Subject: [ferrethealth] something that may cheeer people who have lost ferrets to brain infections
To: ferrethealth@yahoogroups.com
There is some new progress in being able to ferry drugs across the blood-brain barrier
using a molecule from the rabies virus:
http://www.sciencenews.org/articles/20070623/fob1.asp
Although early days I know there are people here who have had ferrets or gotten ferrets
into shelters with brain centered infections in the past, and now such victims may
eventually be able to be helped by this in conjunction with other research. So, it will cheer
people to see such progress.
BEGIN QUOTES
The molecule from the rabies virus acts as a key that corresponds to keyhole molecules on
the surfaces of the capillary walls... [and] triggers a poorly understood process that moves
it through the wall, carrying the drug with it.
...
"This [research] has enormous ramifications for many neurological-disease categories,"
...
Many questions remain before the new technique can be used on [patients]... [including]
whether some regions of the brain receive more of the drug than others and whether
[an] ... immune system might eventually neutralize the rabies molecule.
END QUOTES
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