From:
Sukie Crandall
Date: 2007-07-20 19:56:16 UTC
Subject: [ferrethealth] melatonin implant and lupron injections? (adrenal disease) - France
To: ferrethealth@yahoogroups.com
http://www.ncbi.nlm.nih.gov/sites/entrez
From PubMed:
> Am J Vet Res. 2005 May;66(5):910-4.
> Links
> Clinical and endocrine responses to treatment with deslorelin=20
> acetate implants in ferrets with adrenocortical disease.
>
> Wagner RA, Pich=E9 CA, J=F6chle W, Oliver JW.
> Division of Laboratory Animal Resources, 3500 Terrace St, S1049=20
> BST, University of Pittsburgh, Pittsburgh, PA 15261, USA.
> OBJECTIVE: To evaluate the clinical and endocrine responses of=20
> ferrets with adrenocortical disease (ACD) to treatment with a slow-
> release implant of deslorelin acetate. ANIMALS: 15 ferrets with=20
> ACD. PROCEDURE: Ferrets were treated SC with a single slow-release,=20
> 3-mg implant of deslorelin acetate. Plasma estradiol,=20
> androstenedione, and 17-hydroxyprogesterone concentrations were=20
> measured before and after treatment and at relapse of clinical=20
> signs; at that time, the adrenal glands were grossly or=20
> ultrasonographically measured and affected glands that were=20
> surgically removed were examined histologically. RESULTS: Compared=20
> with findings before deslorelin treatment, vulvar swelling,=20
> pruritus, sexual behaviors, and aggression were significantly=20
> decreased or eliminated within 14 days of implantation; hair=20
> regrowth was evident 4 to 6 weeks after treatment. Within 1 month=20
> of treatment, plasma hormone concentrations significantly decreased=20
> and remained decreased until clinical relapse. Mean time to=20
> recurrence of clinical signs was 13.7 +/- 3.5 months (range, 8.5 to=20
> 20.5 months). In 5 ferrets, large palpable tumors developed within=20
> 2 months of clinical relapse; 3 of these ferrets were euthanatized=20
> because of adrenal gland tumor metastasis to the liver or tumor=20
> necrosis. CONCLUSIONS AND CLINICAL RELEVANCE: In ferrets with ACD,=20
> a slow-release deslorelin implant appears promising as a treatment=20
> to temporarily eliminate clinical signs and decrease plasma steroid=20
> hormone concentrations. Deslorelin may not decrease adrenal tumor=20
> growth in some treated ferrets. Deslorelin implants may be useful=20
> in the long-term management of hormone-induced sequelae in ferrets=20
> with ACD and in treatment of animals that are considered at=20
> surgical or anesthetic risk.
> PMID: 15934621 [PubMed - indexed for MEDLINE]
Here is one of his older papers
> J Am Vet Med Assoc. 2001 Apr 15;218(8):1272-4.
> Links
> Leuprolide acetate treatment of adrenocortical disease in ferrets.
>
> Wagner RA, Bailey EM, Schneider JF, Oliver JW.
> Department of Laboratory Animal Resources, School of Health=20
> Sciences, University of Pittsburgh, PA 15261, USA.
> OBJECTIVE: To determine the effects of leuprolide acetate, a long-
> acting gonadotropin-releasing hormone analog, in ferrets with=20
> adrenocortical diseases. DESIGN: Case series. ANIMALS: 20 ferrets=20
> with adrenocortical disease diagnosed on the basis of clinical=20
> signs and plasma sex hormone concentrations. PROCEDURE: Ferrets=20
> were treated with leuprolide (100 microg, IM, once), and plasma=20
> hormone concentrations were measured before and 3 to 6 weeks after=20
> treatment. RESULTS: Leuprolide treatment resulted in significant=20
> reductions in plasma estradiol, 17 alpha-hydroxyprogesterone,=20
> androstenedione, and dehydroepiandrosterone concentrations and=20
> eliminated or reduced clinical signs associated with adrenocortical=20
> disease. Decreases in vulvar swelling, pruritus, and undesirable=20
> sexual behaviors and aggression were evident 14 days after=20
> treatment; hair regrowth was evident by 4 weeks after treatment.=20
> The response to treatment was transitory, and clinical signs=20
> recurred in all ferrets. Mean +/- SEM time to recurrence was 3.7=20
> +/- 0.4 months (range, 1.5 to 8 months). CONCLUSIONS AND CLINICAL=20
> RELEVANCE: Results suggest that leuprolide can be safely used to=20
> temporarily eliminate clinical signs and reduce sex hormone=20
> concentrations in ferrets with adrenocortical diseases. However,=20
> the safety of long-term leuprolide use in ferrets has not been=20
> investigated, and the long-term effects of leuprolide in ferrets=20
> with nodular adrenal gland hyperplasia or adrenal gland tumors are=20
> unknown.
> PMID: 11330611 [PubMed - indexed for MEDLINE]
Dr. Schoemaker's disseration on the topic:
http://igitur-archive.library.uu.nl/dissertations/2003-1128-094343/
inhoud.htm
and his work continues
Let's see if
http://nal.usda.gov/awic/pubs/Ferrets06/ferrets.htm#contents
may help you, too
(and you can link to two earlier listings of ferret health studies=20
sequentially from it)
Besides Introduction and general the areas which can be opened are=20
the ones below and there seem to be at least a half dozen in the=20
Neoplasia/Tumor section on adrenal growths in ferrets.
Anatomy | Anesthesia / Analgesia | Animal Models | Auditory / Hearing=20
| Biology | Blackfooted Ferrets | Care / Housing | Circulatory /=20
Cardiovascular | Dental | Digestive System | Diseases | Emesis |=20
Enrichment | Feeding / Nutrition / Metabolism | Neoplasia / Tumors |=20
Neurological/Nervous System | Parasites | Reproductive | Research |=20
Veterinary | Viruses
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/ *****REMEMBER=20
TO SEARCH IN HERE, TOO*****
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/fhc/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
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