From:
Sukie Crandall
Date: 2007-07-30 02:38:59 UTC
Subject: [ferrethealth] albinism in ferrets: Abstract
To: ferret-genetics@yahoogroups.com, ferrethealth@yahoogroups.com
> Anim Genet. 2007 Aug;38(4):421-3.
>
>
> Identification of a tyrosinase (TYR) exon 4 deletion in albino
> ferrets (Mustela putorius furo).
>
> Blaszczyk WM, Distler C, Dekomien G, Arning L, Hoffmann KP, Epplen JT.
> General Zoology & Neurobiology, and International Graduate School
> of Neuroscience, Ruhr-University, 44780 Bochum, Germany.
> Albinism is due to a lack of pigmentation in hair, skin and eye,
> and has been shown to occur in several animal species. Mutations of
> the tyrosinase (TYR) gene account for albinism in domestic cats,
> rabbits, cattle, mice and rats. In this study, we demonstrate that
> a TYR mutation accounts for albinism in the ferret (Mustela
> putorius furo). The coding sequence of the five exons of TYR was
> determined in genomic DNA from wild-type pigmented 'sable' coloured
> and albino ferrets. It was not possible to amplify TYR exon 4 in
> albino ferrets originating from different breeds. The deletion of
> exon 4 in albino ferrets was confirmed by Southern blot
> hybridization of genomic DNA from albino and pigmented ferrets.
> This is the first report of a deletion of a TYR exon in a non-human
> mammal.
> PMID: 17655555 [PubMed - in process]
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/fhc/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
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