Message Number: FHL2089 | New FHL Archives SearchFrom: Sukie Crandall
Date: Sat, 04 Aug 2007 15:28:55 -0400
To: ferret-l@LISTSERV.FERRETMAILINGLIST.ORG, Kris Kalaster <ladyhawk_12_22@YAHOO.COM>, ferrethealth@yahoogroups.com
Subject: [ferrethealth] Diabetes and kidney damage: Look what I accidently ran into
I was searching for something else but this may help the FML member
whose ferret has diabetes although it does not seem to be a ferret
study and is in an early stage of study:
> J Pineal Res. 2007 Mar;42(2):203-9.
>
> Links
> Melatonin is more effective than taurine and 5-hydroxytryptophan
> against hyperglycemia-induced kidney-cortex tubules injury.
>
> Derlacz RA, Sliwinska M, Piekutowska A, Winiarska K, Drozak J,
> Bryla J.
> Department of Metabolic Regulation, Institute of Biochemistry,
> Faculty of Biology, Warsaw University, Warsaw, Poland.
> The antioxidative effects of melatonin (Mel), 5-hydroxytryptophan
> (5-HTP) and taurine (TAU) on hyperglycemia-induced oxidative stress
> was investigated in primary cultures of kidney-cortex tubule cells
> grown in metabolically and hormonally defined medium. In the
> presence of 30 mm glucose (hyperglycemic conditions), cell
> viability was decreased by about 35% in comparison with that
> estimated in the glucose-depleted medium probably as a result of
> induction of apoptosis, as concluded from: (i) chromatin
> condensation and DNA fragmentation assays, (ii) a significant
> enhancement of reactive oxygen species (ROS) production, (iii) 8-
> hydroxydeoxyguanosine (8-OHdG) generation, (iv) an increased
> protein peroxidation and (v) a decline of reduced glutathione (GSH)
> levels leading to a disturbed glutathione redox state. The addition
> of 100 microm Mel to the hyperglycemic medium resulted in a twofold
> decrease in both 8-OHdG accumulation and protein peroxidation as
> well as restoration of the control intracellular ROS levels
> accompanied by a substantial increase in GSH/oxidized glutathione
> (GSSG) ratio due to a decline in GSSG content. ROS elimination was
> also achieved in the presence of 1 mm TAU which diminished protein
> and DNA injuries by about 25% and 30%, respectively. On the
> contrary, the action of 100 microm 5-HTP on ROS level, 8-OHdG
> generation, protein peroxidation and GSH/GSSG ratio was negligible.
> Thus, in contrast to 5-HTP and TAU, Mel might be considered as
> beneficial for diabetes therapy, particularly in terms of reduction
> of hyperglycemia-induced kidney injury.
> PMID: 17286753 [PubMed - indexed for MEDLINE]
Sukie (not a vet)
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