From:
"Sukie Crandall"
Date: 2007-08-17 18:11:02 UTC
Subject: [ferrethealth] Re: Dosage of prednisone for insulinoma
To: ferrethealth@yahoogroups.com
The 5 mg/ml gives the concentration which is needed, but you didn't say what volume (ml)
you are giving. Both are needed to figure out how much in mg the ferret is getting.
Typically, one sees what works. If the liver is compromised then Prednisolone will work
better than Prednisone because the liver processing step which turns Prednisone into
Prednisolone before the body can use it is skipped.
How much is used varies with how well the individual responds according to blood tests.
Some factors that affect that are level of disease, size of the animal, and more. So, what is
done is a dose is tried and then if the effects are off it is adjusted.
Here are some ranges from past vet texts, but know that when tolerated there have been
individuals who have gone higher when the choices were between a rock and a hard place,
ditto splitting to 3 doses per day rather than two
>From _Essentials of Ferrets, a Guide for Practitioners_ by Karen Purcell, 1999:
0.1 - 2.5 mg/kg q 12-24 h PO
_Ferrets, Rabbits, and Rodents, clinical medicine and surgery_, Katherine Quesenberry and
James Carpenter, 2004:
0.5 - 2.0 mg/kg q 12 - 24 h PO
_Ferret Husbandry, Medicine and Surgery_, John Lewington, 2007:
0.10 -2.5 mg/kg s.i.d. b.i.d. p.o.
DO give the Pred with FOOD to shield the stomach.
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/fhc/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
(BTW, did anyone notice that a bone building protein has now been found to have an
hormonal effect on levels of insulin produced? Karsenty et. al. of Columbia found that
Osteocalcin which is produced by Osteoblasts increases insulin levels and responsiveness
to insulin. So, bones join fat is having unexpected endocrinological interactions in a
mouse study. The report is in the August 10th issue of Cell.)
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