From:
Sukie Crandall
Date: 2007-09-21 04:54:39 UTC
Subject: [ferrethealth] asthma in ferrets: an abstract
To: ferrethealth@yahoogroups.com
> J Appl Physiol. 2007 Sep 13; [Epub ahead of print]
>
>
> Allergic Lung Inflammation Affects Central Noradrenergic Control of
> Cholinergic Outflow to the Airways in Ferret.
>
> Wilson CG, Akhter S, Mayer CA, Kc P, Balan KV, Ernsberger P, Haxhiu
> MA.
> Pediatrics, Case Western Reserve University, Cleveland, Ohio,
> United States.
> Brainstem noradrenergic cell groups mediating autonomic responses
> to stress project to airway-related vagal preganglionic neurons
> (AVPNs). In ferrets, their activation produces withdrawal of
> cholinergic outflow to the airways via release of norepinephrine
> (NE) and activation of alpha2A-adrenergic receptors (alpha2AAR)
> expressed by AVPNs. In these studies we examined the effects of
> allergen exposure of the airway (AE) with ovalbumin (OA) on
> noradrenergic transmission regulating the activity of AVPNs and,
> consequently, airway smooth muscle tone. Experiments were performed
> in vehicle control (CON) and allergen exposed (AE) ferrets.
> Microperfusion of an alpha2A adrenergic receptor (alpha2AAR)
> agonist (guanabenz) in close proximity to AVPNs elicited more
> pronounced effects in CON than AE ferrets, including a decrease in
> unit activity and reflexly evoked responses of putative AVPN
> neurons with a corresponding decrease in cholinergic outflow to the
> airways. While no differences were found in the extent of
> noradrenergic innervation of the AVPNs, RT-PCR and Western blot
> studies demonstrated that AE and repeated exposure to antigen
> significantly reduced expression of alpha2AARs at message and
> protein levels. These findings indicate that, in an animal model of
> allergic asthma, sensitization and repeated challenges with a
> specific allergen diminishes central inhibitory noradrenergic
> modulation of AVPNs, possibly via downregulation of alpha2AAR
> expression by these neurons. Key words: Asthma, Airway-related
> vagal preganglionic neurons, 2A adrenergic receptors, guanabenz, RT-
> PCR.
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/fhc/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
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