From:
Sukie Crandall
Date: 2007-10-14 08:07:31 UTC
Subject: [ferrethealth] abstracts: a confirmed Cushings case and treatment; SARS
To: ferrethealth@yahoogroups.com
> Domest Anim Endocrinol. 2007 Sep 10; [Epub ahead of print]
>
> Links
> Luteinizing hormone-dependent Cushing's syndrome in a pet ferret
> (Mustela putorius furo).
>
> Schoemaker NJ, Kuijten AM, Galac S.
> Division of Avian and Exotic Animal Medicine of the Department of
> Clinical Sciences of Companion Animals, Faculty of Veterinary
> Medicine, Utrecht University, Yalelaan 108, 3584 CM Utrecht, The
> Netherlands.
> Hyperadrenocorticism in ferrets is associated with increased
> circulating concentrations of adrenal androgens, whereas plasma
> concentrations of cortisol and ACTH are usually not affected. Here,
> we report on a 5-year-old castrated male pet ferret (Mustela
> putorius furo) in which the major presenting signs were polyuria
> and polyphagia. Routine biochemistry values were within their
> reference ranges. The urinary corticoid:creatinine ratio (UCCR) was
> increased and the plasma ACTH concentration was suppressed.
> Abdominal ultrasonography revealed an enlarged right adrenal gland
> and atrophy of the left adrenal gland. Administration of hCG
> resulted in an increase of plasma cortisol and androstenedione
> concentrations. Based on these findings LH/hCG-dependent
> hypercortisolism and hyperandrogenism were suspected and treatment
> was started with a depot GnRH-agonist implant containing 9.4mg
> deslorelin. Within 3 weeks after placement of the implant all
> clinical signs had disappeared. Three months later the endocrine
> parameters had normalized, while abdominal ultrasonography revealed
> that the right adrenal gland had diminished in size and the left
> adrenal gland was considered of normal size. No recurrences of
> clinical signs were seen within 2 years after placement of the
> deslorelin implant. At that time urinary corticoid and plasma
> hormone concentrations were within their reference ranges, and no
> further change in the size of the adrenal glands was seen. In
> conclusion, this is the first confirmed case of LH-dependent
> hypercortisolism in a ferret that was treated successfully with a
> depot GnRH-agonist.
> PMID: 17920804 [PubMed - as supplied by publisher]
> J Infect Dis. 2007 Nov 1;196(9):1329-38. Epub 2007 Sep 27.
>
> Links
> Severe acute respiratory syndrome coronavirus infection in
> vaccinated ferrets.
>
> Darnell ME, Plant EP, Watanabe H, Byrum R, St Claire M, Ward JM,
> Taylor DR.
> Laboratory of Hepatitis and Related Emerging Agents, Division of
> Emerging and Transfusion-Transmitted Diseases, Office of Blood
> Research and Review, CBER FDA, Bethesda, MD, 20892, USA.
> Deborah.Taylor@FDA.HHS.gov.
> Background. Development of vaccines to prevent severe acute
> respiratory syndrome (SARS) is limited by the lack of well-
> characterized animal models. Previous vaccine reports have noted
> robust neutralizing antibody and inflammatory responses in ferrets,
> resulting in enhanced hepatitis.Methods. We evaluated the humoral
> immune response and pathological end points in ferrets challenged
> with the Urbani strain of SARS-associated coronavirus (SARS-CoV)
> after having received formalin-inactivated whole-virus vaccine or
> mock vaccine.Results. Humoral responses were observed in ferrets
> that received an inactivated virus vaccine. Histopathological
> findings in lungs showed that infection of ferrets produced
> residual lung lesions not seen in both mock and vaccinated ferrets.
> SARS-CoV infection demonstrated bronchial and bronchiolar
> hyperplasia and perivascular cuffing in ferret lung tissue, as seen
> previously in infected mice. No evidence of enhanced disease was
> observed in any of the ferrets. All of the ferrets cleared the
> virus by day 14, 1 week earlier if vaccinated.Conclusions. The
> vaccine provided mild immune protection to the ferrets after
> challenge; however, there was no evidence of enhanced liver or lung
> disease induced by the inactivated whole-virus vaccine. The ferret
> may provide another useful model for evaluating SARS vaccine safety
> and efficacy.
> PMID: 17922397 [PubMed - in process]
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/fhc/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
[Non-text portions of this message have been removed]
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