From:
Regina Badriya Harrison
Date: 2007-10-25 16:34:41 UTC
Subject: Re: [ferrethealth] Re: when to start diazoxide treatment for insulinoma
To: ferrethealth@yahoogroups.com
>From: "amb5890" <amb5890@yahoo.com>
> Also, I would like
> to start giving
> him the Prednisone 3x a day but I would not be able
> to keep exactly 8
> hours in between. The best I could do would be 10pm,
> 8am, 3pm. and
> that comes to 10hrs, 7hrs, 7hrs. Would that work or
> not???
According to the pharmacy at the animal hospital I go to, there is a two hour window with prednisone (i.e., it doesn't expire at precisely 8 hours, but starts declining around 7 hours and is done around 9 hours). So from what I've been told, what you are proposing should be effective.
I was also told by my vet that you can keep pushing the dosage of pred up as long as you see improvement and that the upper limit is more of a guideline than a hard and fast limit. However, even though ferrets are supposed to tolerate pred comparatively well, I have seen ulcers develop in each of my ferrets who has been on high doses of pred long term for insulinoma or lymphoma, so that's something to consider. I had very good luck with diazoxide in one ferret, it gave her another good six months after pred lost its effectiveness. I'm sorry I don't remember the dosage, it was about six years ago.
regards,
Regina
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