From:
Sukie Crandall
Date: 2007-11-18 01:56:27 UTC
Subject: [ferrethealth] ferret chemokine cloning abstract
To: ferrethealth@yahoogroups.com
> Mol Immunol. 2007 Nov 13; [Epub ahead of print]
> Cloning, expression and characterization of ferret CXCL10.
>
> Danesh A, Seneviratne C, Cameron CM, Banner D, Devries ME, Kelvin
> AA, Xu L, Ran L, Bosinger SE, Rowe T, Czub M, Jonsson CB, Cameron
> MJ, Kelvin DJ.
> Division of Experimental Therapeutics, Toronto General Research
> Institute, University Health Network, 101 College Street, Toronto,
> Ontario, Canada M5G 1L7; Department of Immunology, University of
> Toronto, Toronto, Ontario, Canada.
> Chemokines and their receptors function in the recruitment and
> activation of cells of the immune system to sites of inflammation.
> As such, chemokines play an important role in mediating
> pathophysiological events during microbial infection. In particular,
> CXCL9, CXCL10 and CXCL11 and their cognate receptor CXCR3 have been
> associated with the clinical course of several infectious diseases,
> including severe acute respiratory syndrome (SARS) and influenza.
> While CXCL9, CXCL10 and CXCL11 share the same receptor and have
> overlapping functions, each can also have unique activity in host
> defense. The lack of a preferred characterized animal model for SARS
> has brought our attention to ferrets, which have been used for years
> in influenza studies. The lack of immunological reagents for ferrets
> prompted us to clone CXCL9, CXCL10, CXCL11 and CXCR3 and, in the
> case of CXCL10, to express the gene as a recombinant protein. In
> this study we demonstrate that endogenous ferret CXCL10 exhibits
> similar mRNA expression patterns in the lungs of deceased SARS
> patients and ferrets experimentally infected with SARS coronavirus.
> This study therefore represents an important step towards
> development of the ferret as a model for the role of CXCL9, CXCL10
> and CXCL11:CXCR3 axis in severe viral infections.
> PMID: 18006061 [PubMed - as supplied by publisher]
>
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