From:
"Sukie Crandall"
Date: 2007-12-11 20:14:00 UTC
Subject: [ferrethealth] Re: Another name for Lupron Depot?
To: ferrethealth@yahoogroups.com
These have info on the nuances of how the drug is used in ferrets:
http://lib.bioinfo.pl/pmid:15934621
such as the following quote which I will include due to the high
amount of information in it. Notice that just as AAE (Adrenal
Associated Endocrinopathy) is a formal abbreviation for the
ferret type of adrenal disease so is ACD (Adrenocortical Disease).=20
Notice also the importance of putting in a new implant when
symptoms return and that depending on the individual the
symptoms can return as early as 8.5 months after implant.
Am J Vet Res. 2005 May ;66 (5):910-4 15934621=09
Clinical and endocrine responses to treatment with deslorelin
acetate implants in ferrets with adrenocortical disease.
Robert A Wagner , Claude A Pich=E9 , Wolfgang J=F6chle , Jack W Oliver
OBJECTIVE: To evaluate the clinical and endocrine responses of
ferrets with adrenocortical disease (ACD) to treatment with a
slow-release implant of deslorelin acetate. ANIMALS: 15 ferrets
with ACD. PROCEDURE: Ferrets were treated SC with a single
slow-release, 3-mg implant of deslorelin acetate. Plasma
estradiol, androstenedione, and 17-hydroxyprogesterone
concentrations were measured before and after treatment and at
relapse of clinical signs; at that time, the adrenal glands were
grossly or ultrasonographically measured and affected glands
that were surgically removed were examined histologically.
RESULTS: Compared with findings before deslorelin treatment,
vulvar swelling, pruritus, sexual behaviors, and aggression were
significantly decreased or eliminated within 14 days of implantation;
hair regrowth was evident 4 to 6 weeks after treatment. Within 1
month of treatment, plasma hormone concentrations significantly
decreased and remained decreased until clinical relapse. Mean time
to recurrence of clinical signs was 13.7 +/- 3.5 months (range, 8.5
to 20.5 months). In 5 ferrets, large palpable tumors developed within
2 months of clinical relapse; 3 of these ferrets were euthanatized
because of adrenal gland tumor metastasis to the liver or tumor
necrosis. CONCLUSIONS AND CLINICAL RELEVANCE: In ferrets with
ACD, a slow-release deslorelin implant appears promising as a
treatment to temporarily eliminate clinical signs and decrease plasma
steroid hormone concentrations. Deslorelin may not decrease adrenal
tumor growth in some treated ferrets. Deslorelin implants may be
useful in the long-term management of hormone-induced sequelae
in ferrets with ACD and in treatment of animals that are considered at
surgical or anesthetic risk.
Mesh-terms: Adrenal Cortex Diseases, drug therapy; Adrenal Cortex
Diseases, veterinary; Aging; Animals; Drug Implants, therapeutic use;
Female; Ferrets, blood;Ferrets, physiology; Gonadal Steroid Hormones,
blood; Male; Recurrence; Triptorelin, administration & dosage; Triptorelin,=
adverse effects; Triptorelin, analogs & derivatives; Triptorelin, therapeut=
ic
use;
[Pubmed] [Scholar] [EndNote] [BibTex]
http://lib.bioinfo.pl/auth:Schoemaker,NJ
http://ferrethealth.org/archive/2007/FHL1304
http://www.nal.usda.gov/awic/pubs/Ferrets06/diseases.htm
http://pets.groups.yahoo.com/group/ferrethealth/message/4257
http://igitur-archive.library.uu.nl/dissertations/2003-1128-094343/inhoud.h=
tm
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/fhc/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
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