From:
Sukie Crandall
Date: 2007-04-10 13:53:43 UTC
Subject: [ferrethealth] If an intubated ferret is injured
To: ferrethealth@yahoogroups.com
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?
db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17418268&query_hl=1&i
tool=pubmed_docsum>
BEGIN QUOTE
> Otolaryngol Head Neck Surg. 2007 Apr;136(4):653-7.
> Refining indications for the use of mitomycin C using a randomized
> controlled trial with an animal model.
>
> Shvidler J, Bothwell NE, Cable B.
> Tripler Army Medical Center, Honolulu, HI.
> OBJECTIVES: To evaluate the effect of mitomycin on the repair of
> acquired subglottic stenosis and to define the optimal
> concentration of mitomycin that would minimize restenosis after
> repair. STUDY DESIGN AND SETTING: A randomized prospective model
> was used in which 20 ferrets (Mustela putorius furo) underwent
> simulated intubation injury that was then treated with CO(2) laser
> lysis. RESULTS: Comparison of cross-sectional airway areas, after
> stenosis repair, showed no significant differences between control
> and mitomycin treatment groups. Comparison of histologic scores for
> both inflammation and mucosalization yielded no difference between
> control and treatment animals. CONCLUSIONS: Mitomycin C appeared to
> have no benefit when placed after repair of an acquired stenosis.
> SIGNIFICANCE: This study closely models the injury experienced by
> children with acquired subglottic stenosis. These data provide
> clear evidence that mitomycin is limited in its effect on
> established wounds and help further define its role as an adjuvant
> for surgery in the aerodigestive tract.
> PMID: 17418268 [PubMed - in process]
END QUOTE
Sukie (not a vet)
Current FHL address:
http://groups.yahoo.com/group/ferrethealth
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/fhc/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
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