From:
Sukie Crandall
Date: 2007-04-20 20:48:34 UTC
Subject: [ferrethealth] melamine
To: ferrethealth@yahoogroups.com, Bill Gruber <billgruber@mac.com>
I got an off-list note from someone who was looking into articles on
tissue accumulation of melamine by-products but the person forgot to
include the URL(s), so while I wait on pins and needles for what
promises to be an interesting reference I am hitting some resources.
Certainly, it appeared in the animal tissues of dead animals tested
by Menu Foods. There is still the question if it or any dangerous by-
products may accumulate in dietary animal source tissues over time
(meats, numerous specific organs with the kidneys looking intriguing
for obvious reasons, skin, etc.)
Here is a Material safety Data Sheet for melamine:
http://www.sciencelab.com/xMSDS-Melamine-9924600
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed
BEGIN QUOTE
Food Chem Toxicol. 2004 Dec;42(12):1999-2007.
Neoplastic and preneoplastic lesions induced by melamine in rat
urothelium are modulated by dietary polyunsaturated fatty acids.
Cremonezzi DC, Diaz MP, Valentich MA, Eynard AR.
ARE, Instituto de Biologia Celular, Facultad de Ciencias Medicas,
Universidad Nacional de Cordoba, Casilla de Correos 220, Cordoba,
Argentina.
The modulatory effects of polyunsaturated fatty acids (PUFA) on
urinary tract tumorigenesis of 275 Wistar rats were evaluated by
treating animals with the tumorigenic agent melamine. Rats were fed
with formulae containing 6% of 4 varieties of fats: fish oil enriched
in n-3 PUFA (FO), corn oil enriched in n-6 (CO), olein containing
mainly n-9 oleic acid (O), and 98% stearic acid (SA), the latter two
being essential (EFA)-deficient inducers. Two commercially fed
control groups with (CM) and without (C) melamine were used. Animals
were autopsied at 22-25 and at 36-40 weeks. Hepatic fatty acids
showed that O and SA groups were EFA-deficient. Simple well
differentiated hyperplasias were significantly higher in the FO lot,
whereas dysplasia was increased in the CO, O and SA lots. Most of the
animals fed for 36-40 weeks with the three latter formulae developed
the more severe lesions. Increased urothelial proliferation was more
frequent in EFA-deficient rats. The apoptosis/mitosis ratio was
higher in O, SA and CO fed animals with respect to FO and chow ones.
Results show that dietary PUFA modulate differentially both normal
and pre-neoplastic urothelial proliferation induced by melamine. FO,
rich in n-3 fatty acids, showed a strong protective effect.
END QUOTE
On the bottom of the second page of
http://www.fsis.usda.gov/ophs/clg/Cyromazine.pdf
is
BEGIN QUOTE
This method has been evaluated for cyromazine and melamine residues
analysis
in poultry, red meat tissues, and processed products (ref., J. Agric.
Food Chem.,
1988, 36, 1009-1 01 2).
END QUOTE
But that is not a very eye-friendly reference so I limited in what I
can pull from it, even using assorted search tricks like Clover-f and
font size increases.
Sukie (not a vet)
Current FHL address:
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http://www.miamiferret.org/fhc/
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http://homepage.mac.com/sukie/sukiesferretlinks.html
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